Literature DB >> 26264075

Thymoquinone Anticancer Discovery: Possible Mechanisms.

Ali H El-Far1.   

Abstract

Medicinal plants are known for their many advantages, including the ability to treat diseases such as cancer. Nigella sativa and its active constituent thymoquinone (TQ) have long been used in traditional medicine for treating various conditions related to the respiratory and gastrointestinal systems as well as breast, colorectal, gastric, hepatic, pancreatic cancers and leukemia. TQ has been documented to possess chemo-preventive and chemotherapeutic antitumor effects. Studies reported that TQ inhibits the growth of cancer cells in animal models and culture tumors. This review summarizes the in vitro and in vivo possible mechanisms of TQ anticancer effect.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26264075     DOI： 10.2174/1570163812666150716111821

Source DB:  PubMed          Journal:  Curr Drug Discov Technol        ISSN： 1570-1638


  12 in total

1.  Curcumin, thymoquinone, and 3, 3'-diindolylmethane combinations attenuate lung and liver cancers progression.

Authors:  Amna A Saddiq; Ali H El-Far; Shymaa Abdullah Mohamed Abdullah; Kavitha Godugu; Omar A Almaghrabi; Shaker A Mousa
Journal:  Front Pharmacol       Date:  2022-06-29       Impact factor: 5.988

2.  Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys.

Authors:  Aymen Mabrouk; Hassen Ben Cheikh
Journal:  Libyan J Med       Date:  2016-01       Impact factor: 1.657

3.  Thymoquinone Defeats Diabetes-Induced Testicular Damage in Rats Targeting Antioxidant, Inflammatory and Aromatase Expression.

Authors:  Mustafa S Atta; Essam A Almadaly; Ali H El-Far; Rasha M Saleh; Doaa H Assar; Soad K Al Jaouni; Shaker A Mousa
Journal:  Int J Mol Sci       Date:  2017-04-27       Impact factor: 5.923

Review 4.  Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.

Authors:  Marco Cascella; Giuseppe Palma; Antonio Barbieri; Sabrina Bimonte; Nagoth Joseph Amruthraj; Maria Rosaria Muzio; Vitale Del Vecchio; Domenica Rea; Michela Falco; Antonio Luciano; Claudio Arra; Arturo Cuomo
Journal:  Nutrients       Date:  2017-06-17       Impact factor: 5.717

5.  Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats.

Authors:  Mustafa S Atta; Ali H El-Far; Foad A Farrag; Mohamed M Abdel-Daim; Soad K Al Jaouni; Shaker A Mousa
Journal:  Oxid Med Cell Longev       Date:  2018-10-30       Impact factor: 6.543

6.  Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone.

Authors:  Ali H El-Far; Noureldien H E Darwish; Shaker A Mousa
Journal:  Integr Cancer Ther       Date:  2020 Jan-Dec       Impact factor: 3.279

Review 7.  The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer-A Review on In Vitro, In Vivo, and Clinical Studies.

Authors:  Sylwia Nakonieczna; Aneta Grabarska; Wirginia Kukula-Koch
Journal:  Int J Mol Sci       Date:  2020-11-05       Impact factor: 5.923

8.  Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart.

Authors:  Ali H El-Far; Yaser H A Elewa; Elsayeda-Zeinab A Abdelfattah; Abdel-Wahab A Alsenosy; Mustafa S Atta; Khalid M Abou-Zeid; Soad K Al Jaouni; Shaker A Mousa; Ahmed E Noreldin
Journal:  Int J Mol Sci       Date:  2021-06-25       Impact factor: 5.923

9.  Microenvironmental effects limit efficacy of thymoquinone treatment in a mouse model of ovarian cancer.

Authors:  Andrew J Wilson; Jeanette Saskowski; Whitney Barham; Dineo Khabele; Fiona Yull
Journal:  Mol Cancer       Date:  2015-11-09       Impact factor: 27.401

Review 10.  Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human Diseases.

Authors:  Ali H El-Far; Soad K Al Jaouni; Weikun Li; Shaker A Mousa
Journal:  Nutrients       Date:  2018-09-25       Impact factor: 5.717
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.