| Literature DB >> 26261573 |
Han Wu1, Jun Xie1, Guan-Nan Li1, Qin-Hua Chen1, Ran Li1, Xin-Lin Zhang1, Li-Na Kang1, Biao Xu1.
Abstract
Atrial fibrosis contributes to development and recurrence of atrial fibrillation (AF). TGF-β and periostin have been reported to be involved in fibrogenesis. Here we investigated the role of TGF-β and periostin in atrial fibrosis of AF and in the recurrence of AF after surgery ablation. Western blot, Masson staining, immunohistochemistry and colorimetry were performed to detect the degree of atrial fibrosis and the expression of TGF-β, periostin and collagens in 70 biopsies of right atrial appendage (RAA) obtained in this study. Then the patients who received surgical ablation were followed up for about one year. The results showed an increasing gradient of atrial expression of TGF-β, periostin and collagens paralleled by a higher level of atrial fibrosis in control, SR and AF groups. The expression of TGF-β and periostin was significantly correlated with fibrotic markers. In addition, LAD and the expression of TGF-β were larger or higher in recurrence group than that in nonrecurrence group after surgery ablation. The results suggest that upregulated expression of TGF-β and periostin in RAAs is correlated with the degree of atrial fibrosis in patients with AF.Entities:
Keywords: Periostin; atrial fibrillation; fibrosis; recurrence; transforming growth factor-β
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Year: 2015 PMID： 26261573 PMCID： PMC4525907
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625