| Literature DB >> 26261535 |
Ying Liu1, Changzheng Shi2, Meng Cui2, Zhenhua Yang1, Danhui Gan3, Yiming Wang1.
Abstract
The aim of this study is to investigate whether partial liver irradiation promotes hepatic regeneration in rat. Left-half liver of rat was irradiated to 10 Gy, and the Right-half to 0, 5, 10 and 15 Gy, respectively. Then, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels were evaluated on 0 day, 15-day, 30-day, 45-day and 60-day after liver irradiation. Next, the serum HGF, NF-κB and TGF-β1 levels were also analyzed on 60-day after liver irradiation. Lastly, the cyclinD1 protein expression was appraised by western blots on 60-day after liver irradiation. ALT, AST and ALP levels were reduced compared with that of controls. The serum HGF, NF-κB and TGF-β1 levels, and the cyclinD1 protein expression in liver irradiation group were increased compared with that of controls group. However, hepatic regeneration of higher dose-irradiated cirrhotic liver was triggered a more enhanced regeneration, compared with that of higher doses group. In summary, these results suggest that different doses of partial liver irradiation promotes hepatic regeneration in rat.Entities:
Keywords: HGF; Liver irradiation; NF-κB; TGF-β1; hepatic regeneration
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Year: 2015 PMID： 26261535 PMCID： PMC4525869
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625