Paul Studenic1, Tanja Stamm1, Josef S Smolen2, Daniel Aletaha3. 1. Division of Rheumatology, Department of Internal Medicine 3, Medical University Vienna and. 2. Division of Rheumatology, Department of Internal Medicine 3, Medical University Vienna and 2nd Department of Medicine, Hietzing Hospital, Vienna, Austria. 3. Division of Rheumatology, Department of Internal Medicine 3, Medical University Vienna and daniel.aletaha@meduniwien.ac.at.
Abstract
OBJECTIVE: Patient-reported outcomes (PROs) such as pain, patient global assessment (PGA) and fatigue are regularly assessed in RA patients. In the present study, we aimed to explore the reliability and smallest detectable differences (SDDs) of these PROs, and whether the time between assessments has an impact on reliability. METHODS: Forty RA patients on stable treatment reported the three PROs daily over two subsequent months. We assessed the reliability of these measures by calculating intraclass correlation coefficients (ICCs) and the SDDs for 1-, 7-, 14- and 28-day test-retest intervals. RESULTS: Overall, SDD and ICC were 25 mm and 0.67 for pain, 25 mm and 0.71 for PGA and 30 mm and 0.66 for fatigue, respectively. SDD was higher with longer time period between assessments, ranging from 19 mm (1-day intervals) to 30 mm (28-day intervals) for pain, 19 to 33 mm for PGA, and 26 to 34 mm for fatigue; correspondingly, ICC was smaller with longer intervals, and ranged between the 1- and the 28-day interval from 0.80 to 0.50 for pain, 0.83 to 0.57 for PGA and 0.76 to 0.58 for fatigue. The baseline simplified disease activity index did not have any influence on reliability. Lower baseline PRO scores led to smaller SDDs. CONCLUSION: Reliability of pain, PGA and fatigue measurements is dependent on the tested time interval and the baseline levels. The relatively high SDDs, even for patients in the lowest tertiles of their PROs, indicate potential issues for assessment of the presence of remission.
OBJECTIVE:Patient-reported outcomes (PROs) such as pain, patient global assessment (PGA) and fatigue are regularly assessed in RApatients. In the present study, we aimed to explore the reliability and smallest detectable differences (SDDs) of these PROs, and whether the time between assessments has an impact on reliability. METHODS: Forty RApatients on stable treatment reported the three PROs daily over two subsequent months. We assessed the reliability of these measures by calculating intraclass correlation coefficients (ICCs) and the SDDs for 1-, 7-, 14- and 28-day test-retest intervals. RESULTS: Overall, SDD and ICC were 25 mm and 0.67 for pain, 25 mm and 0.71 for PGA and 30 mm and 0.66 for fatigue, respectively. SDD was higher with longer time period between assessments, ranging from 19 mm (1-day intervals) to 30 mm (28-day intervals) for pain, 19 to 33 mm for PGA, and 26 to 34 mm for fatigue; correspondingly, ICC was smaller with longer intervals, and ranged between the 1- and the 28-day interval from 0.80 to 0.50 for pain, 0.83 to 0.57 for PGA and 0.76 to 0.58 for fatigue. The baseline simplified disease activity index did not have any influence on reliability. Lower baseline PRO scores led to smaller SDDs. CONCLUSION: Reliability of pain, PGA and fatigue measurements is dependent on the tested time interval and the baseline levels. The relatively high SDDs, even for patients in the lowest tertiles of their PROs, indicate potential issues for assessment of the presence of remission.
Authors: Lisanne Renskers; Ron J J C van Uden; Anita M P Huis; Sanne A A Rongen; Steven Teerenstra; Piet L C M van Riel Journal: Clin Rheumatol Date: 2018-09-12 Impact factor: 2.980
Authors: Pushpendra Goswami; Esther N Oliva; Tatyana Ionova; Roger Else; Jonathan Kell; Adele K Fielding; Daniel M Jennings; Marina Karakantza; Saad Al-Ismail; Graham P Collins; Stewart McConnell; Catherine Langton; Magda J Al-Obaidi; Metod Oblak; Sam Salek Journal: Front Pharmacol Date: 2020-10-20 Impact factor: 5.810