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Literature DB >> 26260813

miRNA-15a/16: as tumor suppressors and more.

Enyu Huang¹, Ronghua Liu¹, Yiwei Chu^1,2.

Abstract

Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This review summarizes the history, biological properties and the important functions of these two miRNAs in cancer. It also introduces their roles as regulators of immune responses and angiogenesis, endogenous controls as well as potential targets and hallmarks of cancer.

Entities: Disease Gene

Keywords: angiogenesis; cancer hallmarks; cancer therapy; immune regulator; miRNA

Mesh：

Substances：

Year: 2015 PMID： 26260813 DOI： 10.2217/fon.15.101

Source DB: PubMed Journal: Future Oncol ISSN： 1479-6694 Impact factor: 3.404

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Cited

33 in total

1. Expression profiling of microRNAs and isomiRs in conventional central chondrosarcoma.

Authors: Antonina Parafioriti; Ingrid Cifola; Clarissa Gissi; Eva Pinatel; Laura Vilardo; Elisabetta Armiraglio; Andrea Di Bernardo; Primo Andrea Daolio; Armando Felsani; Igea D'Agnano; Anna Concetta Berardi
Journal: Cell Death Discov Date: 2020-06-10

2. Downregulation of miRNA-15a and miRNA-16 promote tumor proliferation in multiple myeloma by increasing CABIN1 expression.

Authors: Lei Zhang; Lin Zhou; Meng Shi; Yong Kuang; Lei Fang
Journal: Oncol Lett Date: 2017-11-15 Impact factor: 2.967

3. miR-15a and miR-24-1 as putative prognostic microRNA signatures for pediatric pilocytic astrocytomas and ependymomas.

Authors: M Braoudaki; G I Lambrou; K Giannikou; S A Papadodima; A Lykoudi; K Stefanaki; G Sfakianos; A Kolialexi; F Tzortzatou-Stathopoulou; M Tzetis; S Kitsiou-Tzeli; E Kanavakis
Journal: Tumour Biol Date: 2016-01-26

4. Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma.

Authors: Xiyin Wang; Jillian R H Wendel; Robert E Emerson; Russell R Broaddus; Chad J Creighton; Douglas B Rusch; Aaron Buechlein; Francesco J DeMayo; John P Lydon; Shannon M Hawkins
Journal: Oncogene Date: 2020-08-25 Impact factor: 9.867

5. [The regulatory role of microRNA in osteogenic differentiation of mesenchymal stem cells and its application as a therapeutic target and diagnostic tool in orthopedic diseases].

Authors: Xiaolong Li; Qingquan Kong
Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi Date: 2020-10-15

6. MicroRNA-15a/16-1 cluster located at chromosome 13q14 is down-regulated but displays different expression pattern and prognostic significance in multiple myeloma.

Authors: Fei Li; Yan Xu; Shuhui Deng; Zengjun Li; Dehui Zou; Shuhua Yi; Weiwei Sui; Mu Hao; Lugui Qiu
Journal: Oncotarget Date: 2015-11-10

7. Copy number variations of circulating, cell-free DNA in urothelial carcinoma of the bladder patients treated with radical cystectomy: a prospective study.

Authors: Armin Soave; Felix K-H Chun; Timo Hillebrand; Michael Rink; Lars Weisbach; Bettina Steinbach; Margit Fisch; Klaus Pantel; Heidi Schwarzenbach
Journal: Oncotarget Date: 2017-05-07