Elias Johansson1, Jan Ahlqvist2, Maria Garoff3, Eva Levring Jäghagen2, Amanda Meimermondt4, Per Wester5. 1. Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: elias.johansson@umu.se. 2. Associate Professor, Department of Odontology, Umeå University, Umeå, Sweden. 3. Department of Odontology, Umeå University, Umeå, Sweden. 4. Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden. 5. Professor, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Abstract
OBJECTIVE: The aim of this study was to determine whether people with calcifications in the area of the carotid arteries on panoramic radiographs (CALPANs) have an increased prevalence of vascular risk factors or an increased risk of future vascular events. MATERIALS AND METHODS: We included 113 consecutive patients with CALPANs and 116 gender- and age-matched controls without CALPANs. Vascular risk factors were generally known in the study population, since it was recorded in a population-based community-screening program. RESULTS: Patients with CALPANs had a higher prevalence of vascular risk factors than controls independent of previous vascular events. During the 5.4-year follow-up, patients with CALPANs had a higher risk of a combined endpoint of vascular events (5.6%/yr) compared with the controls (2.4%/yr) (P = .004 by log rank test; unadjusted hazard ratio (HR) 2.4; 95% CI 1.3-4.3). This difference was not significant when previous vascular events and risk factors were taken into account (adjusted HR; 1.2; 95% CI 0.6-2.3; P = .62; Cox regression). CONCLUSIONS: People with CALPANs are very likely to have vascular risk factors, but these factors might be unknown when CALPANs are detected. Accordingly, patients with CALPANs should be advised to have their vascular risk factors regularly checked in order to receive advice on preventive lifestyle modifications and medical treatment when indicated. However, it remains unknown whether CALPANs add information about the independent risk of future vascular events. Therefore, further studies are warranted to investigate whether the detection of CALPANs indicates a need for additional or more intense vascular treatment.
OBJECTIVE: The aim of this study was to determine whether people with calcifications in the area of the carotid arteries on panoramic radiographs (CALPANs) have an increased prevalence of vascular risk factors or an increased risk of future vascular events. MATERIALS AND METHODS: We included 113 consecutive patients with CALPANs and 116 gender- and age-matched controls without CALPANs. Vascular risk factors were generally known in the study population, since it was recorded in a population-based community-screening program. RESULTS:Patients with CALPANs had a higher prevalence of vascular risk factors than controls independent of previous vascular events. During the 5.4-year follow-up, patients with CALPANs had a higher risk of a combined endpoint of vascular events (5.6%/yr) compared with the controls (2.4%/yr) (P = .004 by log rank test; unadjusted hazard ratio (HR) 2.4; 95% CI 1.3-4.3). This difference was not significant when previous vascular events and risk factors were taken into account (adjusted HR; 1.2; 95% CI 0.6-2.3; P = .62; Cox regression). CONCLUSIONS:People with CALPANs are very likely to have vascular risk factors, but these factors might be unknown when CALPANs are detected. Accordingly, patients with CALPANs should be advised to have their vascular risk factors regularly checked in order to receive advice on preventive lifestyle modifications and medical treatment when indicated. However, it remains unknown whether CALPANs add information about the independent risk of future vascular events. Therefore, further studies are warranted to investigate whether the detection of CALPANs indicates a need for additional or more intense vascular treatment.
Authors: Maria Garoff; Jan Ahlqvist; Eva Levring Jäghagen; Elias Johansson; Per Wester Journal: Dentomaxillofac Radiol Date: 2016-05-10 Impact factor: 2.419
Authors: Maria Garoff; Jan Ahlqvist; Linda-Tereza Edin; Sofia Jensen; Eva Levring Jäghagen; Fredrik Petäjäniemi; Per Wester; Elias Johansson Journal: BMC Cardiovasc Disord Date: 2019-10-16 Impact factor: 2.298