| Literature DB >> 26260449 |
Natsuko Kondo1, Yoshinori Sakurai2, Takushi Takata3, Nobuhiko Takai4, Yosuke Nakagawa2, Hiroki Tanaka2, Tsubasa Watanabe2, Kyo Kume5, Taichiro Toho6, Shin-ichi Miyatake6, Minoru Suzuki2, Shin-ichiro Masunaga2, Koji Ono2.
Abstract
Brain radiation necrosis is the most serious late adverse event that occurs after 6 months following radiation therapy. Effective treatment for this irreversible brain necrosis has not been established yet. This study tries to establish brain radiation necrosis mouse model using proton or helium beam. The right cerebral hemispheres of C57BL/6J mouse brains were irradiated at doses of 40, 50, 60 Gy with charged particles. In 60 Gy group, brain necrosis that recapitulates human disease was detected after 8 months.Entities:
Keywords: Brain radiation necrosis model; Histology; MRI; Proton beams
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Year: 2015 PMID： 26260449 DOI： 10.1016/j.apradiso.2015.07.032
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513