Tracey L Weissgerber1, Natasa M Milic2, Stephen T Turner3, Reem A Asad4, Thomas H Mosley5, Sharon L R Kardia6, Craig L Hanis7, Vesna D Garovic3. 1. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address: weissgerber.tracey@mayo.edu. 2. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; Medical Faculty, Department of Biostatistics, University of Belgrade, Belgrade, Serbia. 3. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. 4. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; Al Adan Hospital, Ministry of Health, Kuwait. 5. University of Mississippi Medical Center, Jackson. 6. Department of Epidemiology, University of Michigan, Ann Arbor. 7. Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston.
Abstract
OBJECTIVE: To determine whether women who had a hypertensive pregnancy disorder (HPD) have elevated uric acid concentrations decades after pregnancy as compared with women who had normotensive pregnancies. PATIENTS AND METHODS: The Genetic Epidemiology Network of Arteriopathy study measured uric acid concentrations in Hispanic (30%), non-Hispanic white (28%), and non-Hispanic black (42%) women (mean age, 60 ± 10 years). This cross-sectional study was conducted between July 1, 2000, and December 31, 2004. Hispanic participants were recruited from families with high rates of diabetes, whereas non-Hispanic participants were recruited from families with high rates of hypertension. This analysis compared uric acid concentrations in women with a history of normotensive (n = 1846) or hypertensive (n = 408) pregnancies by logistic regression. RESULTS: Women who had an HPD had higher uric acid concentrations (median, 5.7 mg/dL vs 5.3 mg/dL; P < .001) and were more likely to have uric acid concentrations above 5.5 mg/dL (54.4% vs 42.4%; P = .001) than were women who had normotensive pregnancies. These differences persisted after adjusting for traditional cardiovascular risk factors, comorbidities, and other factors that affect uric acid concentrations. A family-based subgroup analysis comparing uric acid concentrations in women who had an HPD (n = 308) and their parous sisters who had normotensive pregnancies (n = 250) gave similar results (median uric acid concentrations, 5.7 mg/dL vs 5.2 mg/dL, P = 0.02; proportion of women with uric acid concentrations > 5.5 mg/dL, 54.0% vs 40.3%, P < .001). CONCLUSION: Decades after pregnancy, women who had an HPD have higher uric acid concentrations. This effect does not appear to be explained by a familial predisposition to elevated uric acid concentrations.
OBJECTIVE: To determine whether women who had a hypertensive pregnancy disorder (HPD) have elevated uric acid concentrations decades after pregnancy as compared with women who had normotensive pregnancies. PATIENTS AND METHODS: The Genetic Epidemiology Network of Arteriopathy study measured uric acid concentrations in Hispanic (30%), non-Hispanic white (28%), and non-Hispanic black (42%) women (mean age, 60 ± 10 years). This cross-sectional study was conducted between July 1, 2000, and December 31, 2004. Hispanic participants were recruited from families with high rates of diabetes, whereas non-Hispanic participants were recruited from families with high rates of hypertension. This analysis compared uric acid concentrations in women with a history of normotensive (n = 1846) or hypertensive (n = 408) pregnancies by logistic regression. RESULTS:Women who had an HPD had higher uric acid concentrations (median, 5.7 mg/dL vs 5.3 mg/dL; P < .001) and were more likely to have uric acid concentrations above 5.5 mg/dL (54.4% vs 42.4%; P = .001) than were women who had normotensive pregnancies. These differences persisted after adjusting for traditional cardiovascular risk factors, comorbidities, and other factors that affect uric acid concentrations. A family-based subgroup analysis comparing uric acid concentrations in women who had an HPD (n = 308) and their parous sisters who had normotensive pregnancies (n = 250) gave similar results (median uric acid concentrations, 5.7 mg/dL vs 5.2 mg/dL, P = 0.02; proportion of women with uric acid concentrations > 5.5 mg/dL, 54.0% vs 40.3%, P < .001). CONCLUSION: Decades after pregnancy, women who had an HPD have higher uric acid concentrations. This effect does not appear to be explained by a familial predisposition to elevated uric acid concentrations.
Authors: G Ndrepepa; S Cassese; S Braun; M Fusaro; L King; T Tada; A Schömig; A Kastrati; R Schmidt Journal: Nutr Metab Cardiovasc Dis Date: 2013-10-04 Impact factor: 4.222
Authors: Courtenay L Diehl; Brian C Brost; Marie C Hogan; Ahmad A Elesber; Keneth P Offord; Stephen T Turner; Vesna D Garovic Journal: Am J Obstet Gynecol Date: 2008-02-01 Impact factor: 8.661
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391