Tianpeng Zheng1, Liuxue Yang1, Yihong Liu1, Hongbo Liu1, Jian Yu1, Xiaoxi Zhang1, Shenghua Qin1. 1. Department of Endocrinology and Metabolism (T.Z., L.Y., J.Y.), Affiliated Hospital of Guilin Medical University, Guangxi 541001, People's Republic of China; Diabetic Centre of Control and Prevention (Y.L.), The People's Liberation Army 520 Hospital, Sichuan 621000, China; Department of Laboratory Medicine (H.L.), Affiliated Hospital of Guilin Medical University, Guangxi 541001, People's Republic of China; Center of Diabetic Systems Medicine (T.Z., X.Z.), Guilin Medical University, Guangxi 541001, People's Republic of China; and Medical Examination Center (S.Q.), Affiliated Hospital of Guilin Medical University, Guangxi 541001, People's Republic of China.
Abstract
CONTEXT: Inflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (GLP-1) are risk factors for osteoporosis. Dipeptidyl peptidase-4 (DPP4) is a newly identified adipokine related to these risk factors. OBJECTIVE: To investigate the association between plasma DPP4 activities and osteoporosis. DESIGN, SETTING, AND PATIENTS: This was a cross-sectional study conducted in Guilin, China. A total of 744 postmenopausal women with normal glucose tolerance were studied. MAIN OUTCOME MEASURES: Plasma DPP4 activity, inflammatory markers, blood lipids, homeostatic model assessment of insulin resistance (HOMA-IR), active GLP-1, bone turnover markers, and bone mineral density (BMD) were measured in all participants. RESULTS: Participants in the highest quartile of DPP4 activity had higher triglyceride, total cholesterol, HOMA-IR, IL-6, high-sensitivity C-reactive protein (hs-CRP), C-terminal telopeptide of type I collagen, and osteocalcin and lower BMD (lumbar spine and femoral neck) and active GLP-1 compared with participants in the lowest quartile (P < .05). DPP4 activities were associated positively with triglyceride, total cholesterol, HOMA-IR, IL-6, hs-CRP, C-terminal telopeptide of type I collagen, and osteocalcin and negatively with active GLP-1 and BMD (P < .05). In the highest DPP4 quartile, osteoporosis risk was significantly higher (odds ratio, 3.01; 95% confidence interval, 1.66-5.43) than in the lowest quartile after adjustment for potential confounders. The risk for osteoporosis increased more with higher levels of DPP4 activity, HOMA-IR, IL-6, and hs-CRP (P < .05), but not with higher levels of triglyceride and total cholesterol or lower levels of active GLP-1. CONCLUSIONS: This study shows that increased DPP4 activities are independently associated with osteoporosis. The mechanisms may be partly explained by the effect of DPP4 on inflammation and insulin resistance.
CONTEXT: Inflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (GLP-1) are risk factors for osteoporosis. Dipeptidyl peptidase-4 (DPP4) is a newly identified adipokine related to these risk factors. OBJECTIVE: To investigate the association between plasma DPP4 activities and osteoporosis. DESIGN, SETTING, AND PATIENTS: This was a cross-sectional study conducted in Guilin, China. A total of 744 postmenopausal women with normal glucose tolerance were studied. MAIN OUTCOME MEASURES: Plasma DPP4 activity, inflammatory markers, blood lipids, homeostatic model assessment of insulin resistance (HOMA-IR), active GLP-1, bone turnover markers, and bone mineral density (BMD) were measured in all participants. RESULTS:Participants in the highest quartile of DPP4 activity had higher triglyceride, total cholesterol, HOMA-IR, IL-6, high-sensitivity C-reactive protein (hs-CRP), C-terminal telopeptide of type I collagen, and osteocalcin and lower BMD (lumbar spine and femoral neck) and active GLP-1 compared with participants in the lowest quartile (P < .05). DPP4 activities were associated positively with triglyceride, total cholesterol, HOMA-IR, IL-6, hs-CRP, C-terminal telopeptide of type I collagen, and osteocalcin and negatively with active GLP-1 and BMD (P < .05). In the highest DPP4 quartile, osteoporosis risk was significantly higher (odds ratio, 3.01; 95% confidence interval, 1.66-5.43) than in the lowest quartile after adjustment for potential confounders. The risk for osteoporosis increased more with higher levels of DPP4 activity, HOMA-IR, IL-6, and hs-CRP (P < .05), but not with higher levels of triglyceride and total cholesterol or lower levels of active GLP-1. CONCLUSIONS: This study shows that increased DPP4 activities are independently associated with osteoporosis. The mechanisms may be partly explained by the effect of DPP4 on inflammation and insulin resistance.
Authors: H Kim; K H Baek; S-Y Lee; S H Ahn; S H Lee; J-M Koh; Y Rhee; C H Kim; D-Y Kim; M-I Kang; B-J Kim; Y-K Min Journal: Osteoporos Int Date: 2016-11-19 Impact factor: 4.507
Authors: Megan M Weivoda; Chee Kian Chew; David G Monroe; Joshua N Farr; Elizabeth J Atkinson; Jennifer R Geske; Brittany Eckhardt; Brianne Thicke; Ming Ruan; Amanda J Tweed; Louise K McCready; Robert A Rizza; Aleksey Matveyenko; Moustapha Kassem; Thomas Levin Andersen; Adrian Vella; Matthew T Drake; Bart L Clarke; Merry Jo Oursler; Sundeep Khosla Journal: Nat Commun Date: 2020-01-07 Impact factor: 14.919