Literature DB >> 26258640

Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.

Joseph R Burgoyne1, Olena Rudyk1, Hyun-Ju Cho1, Oleksandra Prysyazhna1, Natasha Hathaway1, Amanda Weeks2, Rachel Evans3, Tony Ng3, Katrin Schröder4, Ralf P Brandes4, Ajay M Shah5, Philip Eaton1.   

Abstract

Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked to tumorigenesis, rheumatoid arthritis and heart disease. Here we show that pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disulphide between regulatory-RIα subunits of protein kinase A (PKA), which stimulates PKA-dependent ERK signalling. This is crucial to blood vessel growth as 'redox-dead' Cys17Ser RIα knock-in mice fully resistant to PKA disulphide-activation have deficient angiogenesis in models of hind limb ischaemia and tumour-implant growth. Disulphide-activation of PKA represents a new therapeutic target in diseases with aberrant angiogenesis.

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Year:  2015        PMID： 26258640     DOI： 10.1038/ncomms8920

Source DB:  PubMed          Journal:  Nat Commun        ISSN： 2041-1723            Impact factor:   14.919


  34 in total

1.  Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis.

Authors:  Masuko Ushio-Fukai; Yan Tang; Tohru Fukai; Sergey I Dikalov; Yuxian Ma; Mitsuaki Fujimoto; Mark T Quinn; Patrick J Pagano; Chad Johnson; R Wayne Alexander
Journal:  Circ Res       Date:  2002-12-13       Impact factor: 17.367

2.  Hydrogen peroxide generated extracellularly by receptor-ligand interaction facilitates cell signaling.

Authors:  Garrett J DeYulia; Juan M Cárcamo; Oriana Bórquez-Ojeda; Christopher C Shelton; David W Golde
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-28       Impact factor: 11.205

Review 3.  Redox signaling in angiogenesis: role of NADPH oxidase.

Authors:  Masuko Ushio-Fukai
Journal:  Cardiovasc Res       Date:  2006-05-09       Impact factor: 10.787

4.  Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia.

Authors:  Taiki Tojo; Masuko Ushio-Fukai; Minako Yamaoka-Tojo; Satoshi Ikeda; Nikolay Patrushev; R Wayne Alexander
Journal:  Circulation       Date:  2005-05-02       Impact factor: 29.690

5.  Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.

Authors:  AnhCo Nguyen; W Richard Burack; Jeffrey L Stock; Robert Kortum; Oleg V Chaika; Maryam Afkarian; William J Muller; Kenneth M Murphy; Deborah K Morrison; Robert E Lewis; John McNeish; Andrey S Shaw
Journal:  Mol Cell Biol       Date:  2002-05       Impact factor: 4.272

6.  MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial.

Authors: 
Journal:  Lancet       Date:  2002-07-06       Impact factor: 79.321

Review 7.  Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing.

Authors:  Sashwati Roy; Savita Khanna; Chandan K Sen
Journal:  Free Radic Biol Med       Date:  2007-01-19       Impact factor: 7.376

8.  Use of the mouse aortic ring assay to study angiogenesis.

Authors:  Marianne Baker; Stephen D Robinson; Tanguy Lechertier; Paul R Barber; Bernardo Tavora; Gabriela D'Amico; Dylan T Jones; Boris Vojnovic; Kairbaan Hodivala-Dilke
Journal:  Nat Protoc       Date:  2011-12-22       Impact factor: 13.491

9.  NADPH oxidase 4 mediates insulin-stimulated HIF-1α and VEGF expression, and angiogenesis in vitro.

Authors:  Dan Meng; Aihong Mei; Junxu Liu; Xueling Kang; Xianglin Shi; Ruizhe Qian; Sifeng Chen
Journal:  PLoS One       Date:  2012-10-29       Impact factor: 3.240

10.  Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors.

Authors:  Dawid G Nowak; Jeanette Woolard; Elianna Mohamed Amin; Olga Konopatskaya; Moin A Saleem; Amanda J Churchill; Michael R Ladomery; Steven J Harper; David O Bates
Journal:  J Cell Sci       Date:  2008-10-15       Impact factor: 5.285
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  19 in total

1.  Activation of adrenergic receptor in H9c2 cardiac myoblasts co-stimulates Nox2 and the derived ROS mediate the downstream responses.

Authors:  Nikhat Saleem; Shyamal K Goswami
Journal:  Mol Cell Biochem       Date:  2017-06-07       Impact factor: 3.396

Review 2.  Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure.

Authors:  Alexander Dietl; Christoph Maack
Journal:  Curr Heart Fail Rep       Date:  2017-08

3.  Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors.

Authors:  Valeska Helfinger; Florian Freiherr von Gall; Nina Henke; Michael M Kunze; Tobias Schmid; Flavia Rezende; Juliana Heidler; Ilka Wittig; Heinfried H Radeke; Viola Marschall; Karen Anderson; Ajay M Shah; Simone Fulda; Bernhard Brüne; Ralf P Brandes; Katrin Schröder
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-16       Impact factor: 11.205

Review 4.  Regulation of Cardiac PKA Signaling by cAMP and Oxidants.

Authors:  Friederike Cuello; Friedrich W Herberg; Konstantina Stathopoulou; Philipp Henning; Simon Diering
Journal:  Antioxidants (Basel)       Date:  2021-04-24

5.  Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway.

Authors:  Paraskevi Kritsiligkou; Karol Nowicki-Osuch; Zorana Carter; Chris J Kershaw; Declan R Creamer; Alan J Weids; Chris M Grant
Journal:  J Biol Chem       Date:  2021-04-21       Impact factor: 5.157

Review 6.  Roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase in Angiogenesis: Isoform-Specific Effects.

Authors:  Haibo Wang; M Elizabeth Hartnett
Journal:  Antioxidants (Basel)       Date:  2017-06-03

Review 7.  Redox Regulation Beyond ROS: Why ROS Should Not Be Measured as Often.

Authors:  Ralf P Brandes; Flavia Rezende; Katrin Schröder
Journal:  Circ Res       Date:  2018-07-20       Impact factor: 17.367

8.  Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents.

Authors:  Simon Diering; Konstantina Stathopoulou; Mara Goetz; Laura Rathjens; Sönke Harder; Angelika Piasecki; Janice Raabe; Steven Schulz; Mona Brandt; Julia Pflaumenbaum; Ulrike Fuchs; Sonia Donzelli; Sakthivel Sadayappan; Viacheslav O Nikolaev; Frederik Flenner; Elisabeth Ehler; Friederike Cuello
Journal:  J Biol Chem       Date:  2020-08-31       Impact factor: 5.157

9.  The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice.

Authors:  Giulia K Buchmann; Christoph Schürmann; Manuela Spaeth; Wesley Abplanalp; Lukas Tombor; David John; Timothy Warwick; Flávia Rezende; Andreas Weigert; Ajay M Shah; Martin-Leo Hansmann; Norbert Weissmann; Stefanie Dimmeler; Katrin Schröder; Ralf P Brandes
Journal:  Redox Biol       Date:  2021-06-18       Impact factor: 11.799

Review 10.  Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal.

Authors:  Marrit Putker; John Stuart O'Neill
Journal:  Mol Cells       Date:  2016-01-25       Impact factor: 5.034
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