Author's reply.

To the Editor,

We thank to Tekin for her interest in our investigation entitled “Association between restless leg syndrome and slow coronary flow” published in Anatol J Cardiol 2014; 14: 612-6 (1).

Some standard recommendations are made for the quantitative analysis of epicardial blood flow. Pérez de Prado et al. (2) reported that imaging speed should ideally be 25 frames/s. Nevertheless, the corrected TIMI frame count (cTFC) can be calculated at any recording speed, and subsequently it can be expressed in seconds or adjusted to the recommended speed. The images obtained by cineangiography in the study by Gibson et al. (3) were recorded at the rate of 30 frames/s. When we evaluated our findings according to the rate of 30 frames/s, there was no statistically significant change in the association between restless legs syndrome (RLS) and coronary slow flow (CSF).

Ohayon et al. (4) reported RLS prevalence in the general adult population.

A symptom only: ranged from 9.4% to 15%,

A set of symptoms meeting the minimal diagnostic criteria of the international RLS study group: ranged from 3.9% to 14.3%,

Meeting minimal criteria accompanied with a specific frequency and/or severity: ranged from 2.2% to 7.9%,

A differential diagnosis: ranged from 1.9% and 4.6%.

In our study, 33 subjects (38%) had RLS with the CSF phenomenon, and 15 (17%) had RLS without the CSF phenomenon (1). The prevalence of RLS in our control group was slightly higher than the prevalence of Ohayon's (4) study. Previously, we found that (5) the prevalence of RLS in hypertensive patients was more than twice as frequent as that in normotensive individuals (35.3 vs. 17.2%, respectively, p<0.01).

Additionally, there were significant but weak correlations between mean TFC (r=0.268, p<0.001), LAD TFC (r=0.322, p<0.001), and RCA TFC (r=0.117, p=0.02) and severity of RLS. There was no significant correlation between Cx TFC and severity of RLS.