Alfonso González-Valderrama1,2, Carmen Paz Castañeda2, Cristián Mena2, Juan Undurraga2,3, Pilar Mondaca2, Matías Yañez2, Paula Bedregal4, Ruben Nachar1,2. 1. Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile. 2. Early Intervention in Psychosis Program, Instituto Psiquiátrico 'Dr José Horwitz Barak', Santiago, Chile. 3. Department of Psychiatry, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile. 4. Departamento de Salud Publica, Pontificia Universidad Católica de Chile, Santiago, Chile.
Abstract
AIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS: DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
AIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS:DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.
Authors: Atipatsa C Kaminga; Wenjie Dai; Aizhong Liu; Japhet Myaba; Richard Banda; Shi W Wen Journal: Early Interv Psychiatry Date: 2019-02-01 Impact factor: 2.732