| Literature DB >> 26256188 |
Peixiao Tang1, Shanshan Li1, Lili Wang1, Hongqin Yang1, Jin Yan1, Hui Li2.
Abstract
This study aimed to improve the water solubility and reduce the toxicity of chlorzoxazone via complexation with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD). Inclusion complexes between chlorzoxazone and the two cyclodextrins (CDs) were prepared by freeze-drying method. Formation of the complexes was confirmed by FT-IR, PXRD, (1)H NMR, DSC, and SEM. The water solubility and dissolution rates of chlorzoxazone were significantly increased by complexation with the two CDs. Preliminary in vitro cytotoxicity tests showed that the complexes are less toxic to normal liver cells than free chlorzoxazone. In general, the HP-β-CD complex exhibited better dissolution properties than the β-CD complex in various dissolution media. Therefore, the HP-β-CD complex can be used to design novel formulations of chlorzoxazone.Entities:
Keywords: Chlorzoxazone; Chlorzoxazone (PubChem CID: 2733); Dimethyl sulfoxide (PubChem CID: 679); Hydroxypropyl-beta-cyclodextrin (PubChem CID: 14049689); Hydroxypropyl-β-cyclodextrin; In vitro cytotoxicity; Inclusion complex; Methanol (PubChem CID: 887); Solubilization; β-Cyclodextrin; β-Cyclodextrin (PubChem CID: 444041)
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Year: 2015 PMID： 26256188 DOI： 10.1016/j.carbpol.2015.05.055
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381