Adriana Avila Moura1, Maria Júlia Gonçalves de Mello2, Jailson B Correia3. 1. Universidade Federal de Alagoas, Maceió, Brazil. Electronic address: adriana_avila@uol.com.br. 2. Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil; Faculdade Pernambucana de Saúde, Recife, Brazil. 3. Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil; Universidade de Pernambuco, Recife, Brazil.
Abstract
OBJECTIVES: To evaluate prevalences of Treponema pallidum, human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), and hepatitis B virus (HBV) infections and coinfections during prenatal screening in an urban Northeastern Brazilian population through a large dataset. METHODS: Secondary data were obtained from the Maceió (Alagoas, Brazil) municipal prenatal screening program from June 2007 to May 2012. Dried blood serum tests from 54,813 pregnant women were examined to determine prevalences of T. pallidum, HIV, HTLV, and HBV infections and coinfections, and the seroconversion rates for syphilis and HIV infection. Socio-demographic variables associated with syphilis and HIV infection were identified. RESULTS: The prevalences of syphilis, HIV, HTLV, and HBV infections were 2.8%, 0.3%, 0.2%, and 0.4%, respectively. Pregnant women infected with T. pallidum had a 4.62-fold greater risk of HIV coinfection, and pregnant women infected with HIV had a 5.71-fold greater risk of T. pallidum coinfection. Seroconversion for syphilis and HIV during pregnancy occurred in 0.5% and 0.06% of women, respectively. Among the women carrying HTLV, 4.2% also had an HBV infection. CONCLUSIONS: Syphilis was twice as prevalent among pregnant women in Maceió, compared to the national average, and coinfections with syphilis/HIV and HTLV/HBV were significantly associated among these pregnant women.
OBJECTIVES: To evaluate prevalences of Treponema pallidum, human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), and hepatitis B virus (HBV) infections and coinfections during prenatal screening in an urban Northeastern Brazilian population through a large dataset. METHODS: Secondary data were obtained from the Maceió (Alagoas, Brazil) municipal prenatal screening program from June 2007 to May 2012. Dried blood serum tests from 54,813 pregnant women were examined to determine prevalences of T. pallidum, HIV, HTLV, and HBV infections and coinfections, and the seroconversion rates for syphilis and HIV infection. Socio-demographic variables associated with syphilis and HIV infection were identified. RESULTS: The prevalences of syphilis, HIV, HTLV, and HBV infections were 2.8%, 0.3%, 0.2%, and 0.4%, respectively. Pregnant women infected with T. pallidum had a 4.62-fold greater risk of HIV coinfection, and pregnant women infected with HIV had a 5.71-fold greater risk of T. pallidum coinfection. Seroconversion for syphilis and HIV during pregnancy occurred in 0.5% and 0.06% of women, respectively. Among the women carrying HTLV, 4.2% also had an HBV infection. CONCLUSIONS: Syphilis was twice as prevalent among pregnant women in Maceió, compared to the national average, and coinfections with syphilis/HIV and HTLV/HBV were significantly associated among these pregnant women.
Authors: Maria de Fátima Castro Mendes; José de Ribamar Oliveira Lima; Bruna de Oliveira de Melo; Conceição de Maria Fernandes da Silva Pinto; Hermerson Sousa Maia; Thiago Azevedo Feitosa Ferro; Silvio Gomes Monteiro; Edel Figueiredo Barbosa Stancioli; Maria Rosa Quaresma Bomfim Journal: Braz J Microbiol Date: 2020-01-28 Impact factor: 2.476
Authors: Lucy Platt; Clare E French; Catherine R McGowan; Keith Sabin; Erin Gower; Adam Trickey; Bethan McDonald; Jason Ong; Jack Stone; Philippa Easterbrook; Peter Vickerman Journal: J Viral Hepat Date: 2019-12-22 Impact factor: 3.728
Authors: Andres Moreira-Soto; Renata Cabral; Carlos Brites; Jan Felix Drexler; Celia Pedroso; Monika Eschbach-Bludau; Alexandra Rockstroh; Ludy Alexandra Vargas; Ignacio Postigo-Hidalgo; Estela Luz; Gilmara Souza Sampaio; Christian Drosten; Eduardo Martins Netto; Thomas Jaenisch; Sebastian Ulbert; Manoel Sarno Journal: mSphere Date: 2018-08-08 Impact factor: 4.389
Authors: J M Warnecke; M Pollmann; V Borchardt-Lohölter; A Moreira-Soto; S Kaya; A G Sener; E Gómez-Guzmán; L Figueroa-Hernández; W Li; F Li; K Buska; K Zakaszewska; K Ziolkowska; J Janz; A Ott; T Scheper; W Meyer Journal: Epidemiol Infect Date: 2020-10-30 Impact factor: 2.451