Stéphane Potvin1, Andràs Tikàsz2, Ovidiu Lungu3, Alexandre Dumais4, Emmanuel Stip5, Adrianna Mendrek6. 1. Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada. Electronic address: stephane.potvin@umontreal.ca. 2. Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada. 3. Department of Psychiatry, University of Montreal, Montreal, Canada; Centre de recherche de l'Institut Universitaire de Gériatrie de Montréal, Montreal, Canada; Centre for Research in Aging, Donald Berman Maimonides Geriatric Centre, Montreal, Canada. 4. Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Institut Philippe-Pinel de Montréal, Montreal, Canada. 5. Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada; Centre Hospitalier de l'Université de Montréal, Montreal, Canada. 6. Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychology, Bishop's University, Sherbrooke, Canada.
Abstract
OBJECTIVES: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). METHODS: Twenty-two SCZ-TR patients on clozapine, 24 schizophrenia patients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. RESULTS: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. CONCLUSIONS: Treatment resistance is associated with neuro-functional hyper-activations in schizophrenia patients during emotion processing.
OBJECTIVES: To examine the neural correlates of emotion processing in treatment-resistant patients with schizophrenia (SCZ-TR). METHODS: Twenty-two SCZ-TR patients on clozapine, 24 schizophreniapatients on antipsychotics other than clozapine, and 39 healthy controls were scanned using functional neuroimaging while viewing positive, negative and neutral images. RESULTS: Emotionally-laden images (positive and negative) elicited hyper-activations in the dorso-medial prefrontal cortex and left cerebellum in SCZ-TR patients, compared to the two other groups. Similarly, neutral images prompted hyper-activations in the cingulate gyrus in SCZ-TR patients, relative to the two other groups. CONCLUSIONS: Treatment resistance is associated with neuro-functional hyper-activations in schizophreniapatients during emotion processing.
Authors: Martijn G J C Koevoets; Merel Prikken; Doesjka A Hagenaar; René S Kahn; Neeltje E M van Haren Journal: Front Psychiatry Date: 2022-06-15 Impact factor: 5.435