Literature DB >> 26255041

Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria.

Sergej M Ostojic1.   

Abstract

Guanidinoacetic acid (GAA) is a natural precursor of creatine, and a possible substrate for the creatine kinase (CK) enzyme system, serving as a creatine mimetic. Its direct role in cellular bioenergetics has been confirmed in several studies, however GAA utilization by CK seems to be a second-rate as compared to creatine, and compartment-dependent. Here we discuss various factors that might affect GAA use in high-energy phosphoryl transfer in the cytosol and mitochondria.

Entities:  

Keywords:  Bioenergetics; Creatine; Creatine kinase; Guanidinoacetic acid; Mitochondria

Mesh：

Substances：

Year:  2015        PMID： 26255041     DOI： 10.1007/s10863-015-9619-7

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  20 in total

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Review 5.  Creatine deficiency syndromes.

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Review 6.  Creatine and creatinine metabolism.

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Review 7.  Creatine and creatine deficiency syndromes: biochemical and clinical aspects.

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8.  Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.

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10.  Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.

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2.  Effects of guanidinoacetic acid supplementation on nitrogen retention and methionine flux in cattle.

Authors:  Mehrnaz Ardalan; Matt D Miesner; Christopher D Reinhardt; Daniel U Thomson; Cheryl K Armendariz; J Scott Smith; Evan C Titgemeyer
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3.  Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study.

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  3 in total

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