Guy Fagherazzi1, Alice Vilier2, Aurélie Affret2, Beverley Balkau2, Fabrice Bonnet3, Françoise Clavel-Chapelon2. 1. Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, Villejuif, France; Paris-South University, Villejuif, France. Electronic address: guy.fagherazzi@gustaveroussy.fr. 2. Center for Research in Epidemiology and Population Health (CESP), Inserm U1018, Villejuif, France; Paris-South University, Villejuif, France. 3. CHU Rennes, Rennes, France; Inserm U970, Paris, France.
Abstract
PURPOSE: Low birth weight is a well-recognized risk factor for type 2 diabetes (T2D), but less is known about risks associated with the evolution of body shape throughout life with incident T2D in adulthood. METHODS: In 80,110 women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort study, trajectories of self-reported body shapes from age 8 years to 35-40 years were derived using a group-based modeling approach and studied in relation with incident T2D. RESULTS: Compared with women who maintained a stable midrange body shape trajectory from 8 to 40 years, women in all other observed trajectories were at a higher risk of developing T2D in adulthood: The highest risk was observed for women who were lean at age 8 years and had a sharp increase in body shape (hazards ratio = 2.91 [2.35-3.62]); their T2D risk was higher (P for homogeneity = .059) than for women who maintained the largest body shape (hazards ratio = 2.18 [1.76-2.69]). CONCLUSIONS: A group-based modeling approach has identified trajectories of body shape evolution with different risks of developing T2D in adulthood. A sharp increase in body shape after puberty in previously lean girls is a risk factor for the subsequent development of diabetes.
PURPOSE: Low birth weight is a well-recognized risk factor for type 2 diabetes (T2D), but less is known about risks associated with the evolution of body shape throughout life with incident T2D in adulthood. METHODS: In 80,110 women from the Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale (E3N) cohort study, trajectories of self-reported body shapes from age 8 years to 35-40 years were derived using a group-based modeling approach and studied in relation with incident T2D. RESULTS: Compared with women who maintained a stable midrange body shape trajectory from 8 to 40 years, women in all other observed trajectories were at a higher risk of developing T2D in adulthood: The highest risk was observed for women who were lean at age 8 years and had a sharp increase in body shape (hazards ratio = 2.91 [2.35-3.62]); their T2D risk was higher (P for homogeneity = .059) than for women who maintained the largest body shape (hazards ratio = 2.18 [1.76-2.69]). CONCLUSIONS: A group-based modeling approach has identified trajectories of body shape evolution with different risks of developing T2D in adulthood. A sharp increase in body shape after puberty in previously lean girls is a risk factor for the subsequent development of diabetes.
Authors: Q Lisan; M Tafflet; F Thomas; P Boutouyrie; C Guibout; J Haba-Rubio; R Climie; M C Périer; T Van Sloten; B Pannier; P Marques-Vidal; X Jouven; J P Empana Journal: Sci Rep Date: 2019-02-07 Impact factor: 4.379