Literature DB >> 26254726

Down regulation of lncSCIR1 after spinal cord contusion injury in rat.

Jing Wang1, Bo Hu2, Fei Cao2, Shenggang Sun2, Yunjian Zhang2, Qing Zhu3.   

Abstract

Extensive changes occur at transcriptional level after traumatic spinal cord injury (SCI). In this study, we performed a large scale screening of expression changes of long (>200 nt) RNA transcripts including both coding and non-coding RNA species in a rat contusion SCI model. We validated significant down-regulation of one long non-coding RNA (lncSCIR1) at 1, 4, and 7 days postinjury. lncSCIR1 knockdown promoted astrocyte proliferation and migration in vitro. We further validated the strong association between lncSCIR1 knock down and the expression changes of four mRNAs after injury. Our data indicated that lncSCIR1 down-regulation might play a detrimental role in the pathophysiology of traumatic SCI and thereby provided new insights into the studies of potential therapeutic targets for traumatic central nervous system (CNS) injuries.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Astrocyte; Contusion; Long non-coding RNA; RNA-Seq; Spinal cord injury; lncSCIR1

Mesh：

Substances：

Year:  2015        PMID： 26254726     DOI： 10.1016/j.brainres.2015.07.052

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

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Authors:  Zheng Li; Idy H T Ho; Xingye Li; Derong Xu; William K K Wu; Matthew T V Chan; Shugang Li; Xiaodong Liu
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Journal:  J Cell Mol Med       Date:  2018-02-01       Impact factor: 5.310

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