Literature DB >> 26253693

Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?

Isabelle Lamsoul1, Sandrine Uttenweiler-Joseph1, Christel Moog-Lutz1, Pierre G Lutz2.   

Abstract

Ubiquitylation is a reversible post-translational modification of proteins that controls a myriad of functions and cellular processes. It occurs through the sequential action of three distinct enzymes. E3 ubiquitin ligases (E3s) play the role of conductors of the ubiquitylation pathway making them attractive therapeutic targets. This review is dedicated to the largest family of multimeric E3s, the Cullin-RING E3 (CRL) family and more specifically to cullin 5 based CRLs that remains poorly characterized.
Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Entities:  

Keywords:  Cullin RING ligase; E3 ubiquitin ligase; Therapeutic targets; Ubiquitin-proteasome system

Mesh：

Substances：

Year:  2015        PMID： 26253693     DOI： 10.1016/j.biochi.2015.08.003

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  8 in total

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Review 2.  Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma.

Authors:  Kate E Keller; Mary K Wirtz
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3.  Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.

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Journal:  Structure       Date:  2017-06-06       Impact factor: 5.006

4.  Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics.

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Review 5.  Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration.

Authors:  Isabelle Lamsoul; Loïc Dupré; Pierre G Lutz
Journal:  Front Cell Dev Biol       Date:  2020-11-20

6.  Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells.

Authors:  Camille A Spinner; Sandrine Uttenweiler-Joseph; Arnaud Metais; Alexandre Stella; Odile Burlet-Schiltz; Christel Moog-Lutz; Isabelle Lamsoul; Pierre G Lutz
Journal:  Sci Rep       Date:  2015-11-05       Impact factor: 4.379

7.  Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.

Authors:  Hao Zeng; Johnny Castillo-Cabrera; Mika Manser; Bo Lu; Zinger Yang; Vaik Strande; Damien Begue; Raffaella Zamponi; Shumei Qiu; Frederic Sigoillot; Qiong Wang; Alicia Lindeman; John S Reece-Hoyes; Carsten Russ; Debora Bonenfant; Xiaomo Jiang; Youzhen Wang; Feng Cong
Journal:  Elife       Date:  2019-11-19       Impact factor: 8.140

8.  Identification of a cullin5-RING E3 ligase transcriptome signature in glioblastoma multiforme.

Authors:  Shuhua Zheng; Zhenhao Li
Journal:  Aging (Albany NY)       Date:  2020-09-14       Impact factor: 5.682
  8 in total

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