Literature DB >> 26253630

Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies.

Siva S Panda1, Sumaira Liaqat2, Adel S Girgis3, Ahmed Samir4, C Dennis Hall5, Alan R Katritzky5.   

Abstract

Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amino acids; Anti-bacterial; Conjugates; Fluoroquinolone; QSAR; Quinolone

Mesh：

Substances：

Year:  2015        PMID： 26253630     DOI： 10.1016/j.bmcl.2015.07.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors.

Authors:  Hamada H H Mohammed; Doaa Mohamed Elroby Ali; Mohamed Badr; Ahmed G K Habib; Abobakr Mohamed Mahmoud; Sarah M Farhan; Shimaa Salah Hassan Abd El Gany; Soad A Mohamad; Alaa M Hayallah; Samar H Abbas; Gamal El-Din A Abuo-Rahma
Journal:  Mol Divers       Date:  2022-09-24       Impact factor: 3.364

2.  Synthesis, spectral characterization, crystal structure and computational investigation of 2-formyl-6-methoxy-3-carbethoxy quinoline as potential SARS-CoV inhibitor.

Authors:  A Franklin Ebenazer; M Saravanabhavan; K S Ramesh; Shabbir Muhammad; Abdullah G Al-Sehemi; N Sampathkumar
Journal:  J Phys Chem Solids       Date:  2022-07-12       Impact factor: 4.383

Review 3.  Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules.

Authors:  Joanna Fedorowicz; Jarosław Sączewski
Journal:  Monatsh Chem       Date:  2018-06-07       Impact factor: 1.451

4.  Crystal structure and Hirshfeld surface analysis of hexyl 1-hexyl-2-oxo-1,2-di-hydro-quinoline-4-carboxyl-ate.

Authors:  Younos Bouzian; Sevgi Kansiz; Lhassane Mahi; Noureddine Hamou Ahabchane; Joel T Mague; Necmi Dege; Khalid Karrouchi; El Mokhtar Essassi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2020-04-09

5.  Crystal structure, DFT study and Hirshfeld surface analysis of ethyl 6-chloro-2-eth-oxy-quinoline-4-carboxyl-ate.

Authors:  Younos Bouzian; Khalid Karrouchi; El Hassane Anouar; Rachid Bouhfid; Suhana Arshad; El Mokhtar Essassi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-05-31

6.  Efficient Regioselective Synthesis of Novel Water-Soluble 2H,3H-[1,4]thiazino[2,3,4-ij]quinolin-4-ium Derivatives by Annulation Reactions of 8-quinolinesulfenyl Halides.

Authors:  Vladimir A Potapov; Roman S Ishigeev; Svetlana V Amosova
Journal:  Molecules       Date:  2021-02-20       Impact factor: 4.411

Review 7.  Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents.

Authors:  Ana R Millanao; Aracely Y Mora; Nicolás A Villagra; Sergio A Bucarey; Alejandro A Hidalgo
Journal:  Molecules       Date:  2021-11-25       Impact factor: 4.411

8.  Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates.

Authors:  Riham M Bokhtia; Adel S Girgis; Tarek S Ibrahim; Fatma Rasslan; Eman S Nossier; Reham F Barghash; Rajeev Sakhuja; Eatedal H Abdel-Aal; Siva S Panda; Amany M M Al-Mahmoudy
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-03

9.  Design and green synthesis of novel quinolinone derivatives of potential anti-breast cancer activity against MCF-7 cell line targeting multi-receptor tyrosine kinases.

Authors:  Mohamed Mokhtar; Khadijah S Alghamdi; Nesreen S Ahmed; Dina Bakhotmah; Tamer S Saleh
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

10.  Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators.

Authors:  Nagy M Khalifa; Aladdin M Srour; Somaia S Abd El-Karim; Dalia O Saleh; Mohamed A Al-Omar
Journal:  Molecules       Date:  2017-10-26       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.