| Literature DB >> 26253296 |
Yan Ou1, Shuiqin Li2, Xiaojing Zhu3, Baosong Gui3, Ganglian Yao3, Liqun Ma3, Dan Zhu3, Rongguo Fu3, Heng Ge3, Li Wang3, Lining Jia3, Lifang Tian3, Zhaoyang Duan3.
Abstract
Citrate is commonly used as an anticoagulant in hemodialysis for chronic renal failure (CRF) and for the regulation of the immune dysfunction in CRF patients. The objective of this study was to investigate the effect of citrate on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in CRF. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly increased in the CRF model group compared to the control group, and were decreased in the citrate-treated groups. Citrate treatment inhibited the viability of Th17 cells while elevating the viability of Treg cells in CRF rats. Moreover, Th17-related cytokines significantly decreased while the Treg-related cytokines significantly increased with citrate treatment. Moreover, citrate had a negative influence on the deviation of Th17/Treg cells in CRF rats. Therefore, our study suggests that citrate had an anti-inflammatory effect on CRF through the modulation of the Th17/Treg balance.Entities:
Keywords: Th17 cells; chronic renal failure; citrate; regulatory T cells
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Year: 2016 PMID： 26253296 DOI： 10.1007/s10753-015-0225-y
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092