Literature DB >> 26252797

Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis.

Hongbin Jiang1, Jun Zhang2, Zhemin Zhang3, Shengxiang Ren4, Chuansen Zhang1.   

Abstract

Stem cell‑based cell therapy has provided a promising method for the treatment of pulmonary diseases, including idiopathic pulmonary fibrosis (IPF). Furthermore, adipose‑derived stem cells (ADSCs) have been reported to be effective in lung repair and regeneration. In the current study, IPF was induced in mice by intratracheal instillation of bleomycin (BLM), and ADSCs were delivered systemically into the mice via the tail vein to evaluate the effects of ADSC transplantation. The ADSC engraftment rate and morphometric changes in lung tissue samples in vivo were investigated by histochemistry and immunohistochemistry, as well as by western blotting. The results indicated that ADSCs may relieve IPF and provide a significant contribution to lung repair when administered at an early stage.

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Year:  2015        PMID： 26252797     DOI： 10.3892/mmr.2015.4178

Source DB:  PubMed          Journal:  Mol Med Rep        ISSN： 1791-2997            Impact factor:   2.952


  5 in total

Review 1.  Effectivity of mesenchymal stem cells for bleomycin-induced pulmonary fibrosis: a systematic review and implication for clinical application.

Authors:  Yunyu Zhao; Zhipeng Yan; Ying Liu; Yue Zhang; Jie Shi; Jingtao Li; Fanpu Ji
Journal:  Stem Cell Res Ther       Date:  2021-08-23       Impact factor: 6.832

2.  Human Adipose-derived Mesenchymal Stem Cells Attenuate Early Stage of Bleomycin Induced Pulmonary Fibrosis: Comparison with Pirfenidone.

Authors:  Manoj Reddy; Lyle Fonseca; Shashank Gowda; Basavraj Chougule; Aarya Hari; Satish Totey
Journal:  Int J Stem Cells       Date:  2016-11-30       Impact factor: 2.500

3.  Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats.

Authors:  Shangya Chen; Guanqun Cui; Cheng Peng; Martin F Lavin; Xiaoying Sun; Enguo Zhang; Ye Yang; Yingjun Guan; Zhongjun Du; Hua Shao
Journal:  Stem Cell Res Ther       Date:  2018-04-19       Impact factor: 6.832

4.  Adipose-derived stem cells alleviate liver injury induced by type 1 diabetes mellitus by inhibiting mitochondrial stress and attenuating inflammation.

Authors:  Yanli Hou; Wenyu Ding; Peishan Wu; Changqing Liu; Lina Ding; Junjun Liu; Xiaolei Wang
Journal:  Stem Cell Res Ther       Date:  2022-04-01       Impact factor: 6.832

Review 5.  Role of Mesenchymal Stem Cells and Extracellular Vesicles in Idiopathic Pulmonary Fibrosis.

Authors:  Sevindzh Kletukhina; Guzel Mutallapova; Angelina Titova; Marina Gomzikova
Journal:  Int J Mol Sci       Date:  2022-09-23       Impact factor: 6.208
  5 in total

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