Literature DB >> 2625136

Suramin and the inhibitory junction potential in taenia caeci of the guinea-pig.

A Den Hertog1, J Van den Akker, A Nelemans.   

Abstract

The effect of surinam on the inhibitory junction potential evoked in smooth muscle cells of guinea-pig taenia caeci by stimulation of intramural nerves at 22 degrees C was investigated. The amplitude of the inhibitory junction potential was reduced concentration dependently by suramin. The suppression of this response by suramin became less pronounced when the number of stimuli increased (pulse rate: 20/s). These results indicate that suramin reduces the inhibitory junction response by interacting with P2-purinoceptors.

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Year:  1989        PMID： 2625136     DOI： 10.1016/0014-2999(89)90522-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5'-diphosphate.

Authors:  S M Hourani; D A Hall; C J Nieman
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

2.  Characterization of the P1-purinoceptors mediating contraction of the rat colon muscularis mucosae.

Authors:  S J Bailey; D Hickman; S M Hourani
Journal:  Br J Pharmacol       Date:  1992-02       Impact factor: 8.739

3.  Properties of the inhibitory junction potential in smooth muscle of the guinea-pig gastric fundus.

Authors:  N Ohno; L Xue; Y Yamamoto; H Suzuki
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

4.  Characteristic features of inhibitory junction potentials evoked by single stimuli in the guinea-pig isolated taenia caeci.

Authors:  M Bridgewater; T C Cunnane; A F Brading
Journal:  J Physiol       Date:  1995-05-15       Impact factor: 5.182

5.  Neuronal mediators of inhibitory junction potentials and relaxation in the guinea-pig internal anal sphincter.

Authors:  M G Rae; T C Muir
Journal:  J Physiol       Date:  1996-06-01       Impact factor: 5.182

6.  Calcium release from separate receptor-specific intracellular stores induced by histamine and ATP in a hamster cell line.

Authors:  A Den Hertog; B Hoiting; A Molleman; J Van den Akker; M Duin; A Nelemans
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182

7.  Effects of purines on the longitudinal muscle of the rat colon.

Authors:  S J Bailey; S M Hourani
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

8.  P2-purinoceptors mediating spasm of the isolated uterus of the non-pregnant guinea-pig.

Authors:  A S Piper; M Hollingsworth
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

9.  ATP-evoked increases in [Ca2+]i and peptide release from rat isolated neurohypophysial terminals via a P2X2 purinoceptor.

Authors:  J D Troadec; S Thirion; G Nicaise; J R Lemos; G Dayanithi
Journal:  J Physiol       Date:  1998-08-15       Impact factor: 5.182

10.  Effects of suramin on contractions of the guinea-pig vas deferens induced by analogues of adenosine 5'-triphosphate.

Authors:  S J Bailey; S M Hourani
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739
  10 in total

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