Literature DB >> 26251222

Revisiting the hyperhemolysis paradigm.

Mark T Gladwin1.   

Abstract

In this issue of Blood, 2 articles test fundamental hypotheses relating intravascular hemolysis to sickle cell disease (SCD) pathogenesis. Detterich et al confirm a role for hemolysis and cell-free plasma hemoglobin (Hb) in pulmonary and systemic endothelial dysfunction in humans. Almeida et al show in mice that hemolysis induces inflammation that is caused by nitric oxide (NO) scavenging and ameliorated by NO donors and the NO-donor properties of hydroxyurea (HU).

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Year:  2015        PMID： 26251222     DOI： 10.1182/blood-2015-06-649491

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  9 in total

Review 1.  New insights into sickle cell disease: mechanisms and investigational therapies.

Authors:  Gregory J Kato
Journal:  Curr Opin Hematol       Date:  2016-05       Impact factor: 3.284

Review 2.  Pathophysiology and treatment of pulmonary hypertension in sickle cell disease.

Authors:  Victor R Gordeuk; Oswaldo L Castro; Roberto F Machado
Journal:  Blood       Date:  2016-01-12       Impact factor: 22.113

3.  Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.

Authors:  Tamir Kanias; Marion C Lanteri; Grier P Page; Yuelong Guo; Stacy M Endres; Mars Stone; Sheila Keating; Alan E Mast; Ritchard G Cable; Darrell J Triulzi; Joseph E Kiss; Edward L Murphy; Steve Kleinman; Michael P Busch; Mark T Gladwin
Journal:  Blood Adv       Date:  2017-06-27

4.  Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia.

Authors:  Charles T Quinn; Eric P Smith; Shahriar Arbabi; Paramjit K Khera; Christopher J Lindsell; Omar Niss; Clinton H Joiner; Robert S Franco; Robert M Cohen
Journal:  Am J Hematol       Date:  2016-11-08       Impact factor: 10.047

5.  Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease.

Authors:  Erdem Kucukal; Anton Ilich; Nigel S Key; Jane A Little; Umut A Gurkan
Journal:  Am J Hematol       Date:  2018-06-15       Impact factor: 10.047

6.  Hydroxyurea use in Children with Sickle Cell Disease: Do Severely Affected Patients Use It and Does It Impact Hospitalization Outcomes?

Authors:  Susan E Creary; Deena J Chisolm; Terah L Koch; Victoria A Zigmont; Bo Lu; Sarah H O'Brien
Journal:  Pediatr Blood Cancer       Date:  2016-01-21       Impact factor: 3.167

7.  Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation.

Authors:  Zoe Loomis; Paul Eigenberger; Katherine Redinius; Christina Lisk; Vijaya Karoor; Eva Nozik-Grayck; Scott K Ferguson; Kathryn Hassell; Rachelle Nuss; Kurt Stenmark; Paul Buehler; David C Irwin
Journal:  PLoS One       Date:  2017-02-02       Impact factor: 3.240

8.  Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene.

Authors:  Olivier Negre; Anne-Virginie Eggimann; Yves Beuzard; Jean-Antoine Ribeil; Philippe Bourget; Suparerk Borwornpinyo; Suradej Hongeng; Salima Hacein-Bey; Marina Cavazzana; Philippe Leboulch; Emmanuel Payen
Journal:  Hum Gene Ther       Date:  2016-02       Impact factor: 5.695

9.  Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.

Authors:  Victor P Bilan; Frank Schneider; Enrico M Novelli; Eric E Kelley; Sruti Shiva; Mark T Gladwin; Edwin K Jackson; Stevan P Tofovic
Journal:  Pulm Circ       Date:  2018-07-13       Impact factor: 3.017
  9 in total

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