Literature DB >> 26250616

Improving preclinical models of HIV microbicide efficacy.

Nadia R Roan1, Jan Münch2.   

Abstract

Despite potent in vitro efficacy, most topical microbicides fail to effectively prevent HIV transmission. One reason for clinical failure may be that current microbicide testing does not reflect the environment encountered during sexual virus transmission. We discuss how preclinical microbicide development could be improved by more closely mimicking real-life conditions.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV-1; amyloids; microbicide; semen; transmission; vaginal fluid

Mesh：

Substances：

Year:  2015        PMID： 26250616      PMCID： PMC4818646          DOI： 10.1016/j.tim.2015.05.001

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  15 in total

Review 1.  Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers.

Authors:  Gustavo F Doncel; Meredith R Clark
Journal:  Antiviral Res       Date:  2010-12       Impact factor: 5.970

2.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

3.  Variation in virological parameters and antibody responses in macaques after atraumatic vaginal exposure to a pathogenic primary isolate of SIVmac251.

Authors:  O Neildez; R Le Grand; A Chéret; P Caufour; B Vaslin; F Matheux; F Théodoro; P Roques; D Dormont
Journal:  Res Virol       Date:  1998 Jan-Feb

4.  Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.

Authors:  Nadia R Roan; Janis A Müller; Haichuan Liu; Simon Chu; Franziska Arnold; Christina M Stürzel; Paul Walther; Ming Dong; H Ewa Witkowska; Frank Kirchhoff; Jan Münch; Warner C Greene
Journal:  Cell Host Microbe       Date:  2011-12-15       Impact factor: 21.023

5.  Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI.

Authors:  Kyeong-Ae Kim; Maral Yolamanova; Onofrio Zirafi; Nadia R Roan; Ludger Staendker; Wolf-Georg Forssmann; Adam Burgener; Nathalie Dejucq-Rainsford; Beatrice H Hahn; George M Shaw; Warner C Greene; Frank Kirchhoff; Jan Münch
Journal:  Retrovirology       Date:  2010-06-23       Impact factor: 4.602

6.  Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia.

Authors:  C J Miller; M Marthas; J Torten; N J Alexander; J P Moore; G F Doncel; A G Hendrickx
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

7.  Human seminal plasma abrogates the capture and transmission of human immunodeficiency virus type 1 to CD4+ T cells mediated by DC-SIGN.

Authors:  Juan Sabatté; Ana Ceballos; Silvina Raiden; Mónica Vermeulen; Karen Nahmod; Julián Maggini; Gabriela Salamone; Horacio Salomón; Sebastian Amigorena; Jorge Geffner
Journal:  J Virol       Date:  2007-10-03       Impact factor: 5.103

8.  Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.

Authors:  Carol Lackman-Smith; Clay Osterling; Katherine Luckenbaugh; Marie Mankowski; Beth Snyder; Gareth Lewis; Jeremy Paull; Albert Profy; Roger G Ptak; Robert W Buckheit; Karen M Watson; James E Cummins; Brigitte E Sanders-Beer
Journal:  Antimicrob Agents Chemother       Date:  2008-03-03       Impact factor: 5.191

9.  Semen-derived amyloid fibrils drastically enhance HIV infection.

Authors:  Jan Münch; Elke Rücker; Ludger Ständker; Knut Adermann; Christine Goffinet; Michael Schindler; Steffen Wildum; Raghavan Chinnadurai; Devi Rajan; Anke Specht; Guillermo Giménez-Gallego; Pedro Cuevas Sánchez; Douglas M Fowler; Atanas Koulov; Jeffery W Kelly; Walther Mothes; Jean-Charles Grivel; Leonid Margolis; Oliver T Keppler; Wolf-Georg Forssmann; Frank Kirchhoff
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

10.  Novel vaginal microflora colonization model providing new insight into microbicide mechanism of action.

Authors:  Raina N Fichorova; Hidemi S Yamamoto; Mary L Delaney; Andrew B Onderdonk; Gustavo F Doncel
Journal:  MBio       Date:  2011-10-25       Impact factor: 7.867
View more
  9 in total

Review 1.  Amyloid formation: functional friend or fearful foe?

Authors:  P Bergman; N R Roan; U Römling; C L Bevins; J Münch
Journal:  J Intern Med       Date:  2016-05-06       Impact factor: 8.989

Review 2.  Structure, function and antagonism of semen amyloids.

Authors:  Annika Röcker; Nadia R Roan; Jay Kant Yadav; Marcus Fändrich; Jan Münch
Journal:  Chem Commun (Camb)       Date:  2018-07-05       Impact factor: 6.222

3.  Epigallocatechin Gallate Inhibits Macaque SEVI-Mediated Enhancement of SIV or SHIV Infection.

Authors:  Run-Hong Zhou; Le Guo; Jin-Biao Liu; Hang Liu; Wei Hou; Tong-Cui Ma; Xu Wang; Jian-Guo Wu; Li Ye; Wen-Zhe Ho; Jie-Liang Li
Journal:  J Acquir Immune Defic Syndr       Date:  2017-06-01       Impact factor: 3.731

4.  A molecular tweezer antagonizes seminal amyloids and HIV infection.

Authors:  Edina Lump; Laura M Castellano; Christoph Meier; Janine Seeliger; Nelli Erwin; Benjamin Sperlich; Christina M Stürzel; Shariq Usmani; Rebecca M Hammond; Jens von Einem; Gisa Gerold; Florian Kreppel; Kenny Bravo-Rodriguez; Thomas Pietschmann; Veronica M Holmes; David Palesch; Onofrio Zirafi; Drew Weissman; Andrea Sowislok; Burkhard Wettig; Christian Heid; Frank Kirchhoff; Tanja Weil; Frank-Gerrit Klärner; Thomas Schrader; Gal Bitan; Elsa Sanchez-Garcia; Roland Winter; James Shorter; Jan Münch
Journal:  Elife       Date:  2015-08-18       Impact factor: 8.140

Review 5.  Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides.

Authors:  Ignacio Rodríguez-Izquierdo; Daniel Sepúlveda-Crespo; Jose María Lasso; Salvador Resino; Ma Ángeles Muñoz-Fernández
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2022-01-12

6.  Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants.

Authors:  Andrea Introini; Stéphanie Boström; Frideborg Bradley; Anna Gibbs; Axel Glaessgen; Annelie Tjernlund; Kristina Broliden
Journal:  PLoS Pathog       Date:  2017-05-19       Impact factor: 6.823

7.  Semen amyloids participate in spermatozoa selection and clearance.

Authors:  Nadia R Roan; Nathallie Sandi-Monroy; Nargis Kohgadai; Shariq M Usmani; Katherine G Hamil; Jason Neidleman; Mauricio Montano; Ludger Ständker; Annika Röcker; Marielle Cavrois; Jared Rosen; Kara Marson; James F Smith; Christopher D Pilcher; Friedrich Gagsteiger; Olena Sakk; Michael O'Rand; Polina V Lishko; Frank Kirchhoff; Jan Münch; Warner C Greene
Journal:  Elife       Date:  2017-06-27       Impact factor: 8.140

8.  Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques.

Authors:  J B Liu; J L Li; K Zhuang; H Liu; X Wang; Q H Xiao; X D Li; R H Zhou; L Zhou; T C Ma; W Zhou; M Q Liu; W Z Ho
Journal:  Mucosal Immunol       Date:  2018-05-31       Impact factor: 7.313

9.  Binding of Elementary Bodies by the Opportunistic Fungal Pathogen Candida albicans or Soluble β-Glucan, Laminarin, Inhibits Chlamydia trachomatis Infectivity.

Authors:  Michael D Kruppa; Jeremy Jacobs; Kelsey King-Hook; Keleigh Galloway; Amy Berry; Jennifer Kintner; Judy D Whittimore; Rolf Fritz; Robert V Schoborg; Jennifer V Hall
Journal:  Front Microbiol       Date:  2019-01-14       Impact factor: 5.640
  9 in total

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