Literature DB >> 26250367

Acute myeloid leukaemia with t(8;21)(q22;q22.3) and loss of the X chromosome.

Muhajir Mohamed1, Karen Dun2.   

Abstract

Cytogenetic abnormalities occur in approximately 60% of newly diagnosed patients with acute myeloid leukaemia (AML) and are useful in the risk stratification of AML. Translocation between chromosomes 8 and 21-t(8;21)-(q22;q22.3), which carries a favourable prognosis, is found in approximately 5% to 10% of all patients with AML. Additional chromosomal abnormalities have been described in patients with AML with t(8;21), which may impact on the favourable prognosis. We report a patient who had AML with t(8;21)(q22;q22.3) and loss of the X chromosome. 2015 BMJ Publishing Group Ltd.

Entities:  

Mesh：

Year:  2015        PMID： 26250367      PMCID： PMC4533636          DOI： 10.1136/bcr-2015-210855

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  6 in total

1.  Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO.

Authors:  F Kuchenbauer; S Schnittger; T Look; G Gilliland; D Tenen; T Haferlach; W Hiddemann; C Buske; C Schoch
Journal:  Br J Haematol       Date:  2006-09       Impact factor: 6.998

2.  Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.

Authors:  S A Pileri; S Ascani; M C Cox; C Campidelli; F Bacci; M Piccioli; P P Piccaluga; C Agostinelli; S Asioli; D Novero; M Bisceglia; M Ponzoni; A Gentile; P Rinaldi; V Franco; D Vincelli; A Pileri; R Gasbarra; B Falini; P L Zinzani; M Baccarani
Journal:  Leukemia       Date:  2006-12-14       Impact factor: 11.528

3.  Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

Authors:  David Grimwade; Robert K Hills; Anthony V Moorman; Helen Walker; Stephen Chatters; Anthony H Goldstone; Keith Wheatley; Christine J Harrison; Alan K Burnett
Journal:  Blood       Date:  2010-04-12       Impact factor: 22.113

4.  Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).

Authors:  N Boissel; H Leroy; B Brethon; N Philippe; S de Botton; A Auvrignon; E Raffoux; T Leblanc; X Thomas; O Hermine; B Quesnel; A Baruchel; G Leverger; H Dombret; C Preudhomme
Journal:  Leukemia       Date:  2006-06       Impact factor: 11.528

5.  Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival.

Authors:  Daniel A Arber; Anthony S Stein; Nora H Carter; David Ikle; Stephen J Forman; Marilyn L Slovak
Journal:  Am J Clin Pathol       Date:  2003-05       Impact factor: 2.493

6.  Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.

Authors:  Håkon Reikvam; Kimberley Joanne Hatfield; Astrid Olsnes Kittang; Randi Hovland; Øystein Bruserud
Journal:  J Biomed Biotechnol       Date:  2011-05-03
  6 in total

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