Literature DB >> 26250055

Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection.

Karolina Rembeck1, Martin Lagging1.   

Abstract

Chronic HCV infection comprises a broad spectrum of liver disease, ranging from no or minimal activity to active hepatitis that in time may progress to severe liver fibrosis, cirrhosis and hepatocellular carcinoma if left untreated. This review describes the impact of genetic variants of interleukin 28B (IL28B; also known as interferon-lambda 3), inosine triphosphate pyrophosphatase (ITPA) and patatin-like phospholipase domain-containing 3 (PNPLA3) on therapeutic outcome and liver disease severity in HCV-infected patients.

Entities:  

Keywords:  HCV; IL28B; ITPA; ITPase; PNPLA3; genetic variant; histology; inosine triphosphate pyrophosphatase; interferon-λ; natural history; therapy

Mesh：

Substances：

Year:  2015        PMID： 26250055     DOI： 10.2217/pgs.15.65

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN： 1462-2416            Impact factor:   2.533


  9 in total

1.  Treatment of chronic hepatitis C genotype 3 with Sofosbuvir-based therpy: a real-life study.

Authors:  Sandeep Singh Sidhu; Nirmaljeet Singh Malhi; Omesh Goyal; Rupinder Singh; Usha Dutta; Rajiv Grover; J S Sidhu; Vijay Nanda; Harmeet Saluja; Ajesh Bansal; Gursewak Singh; Alok Sehgal; Harsh Kishore; Simran Sidhu
Journal:  Hepatol Int       Date:  2017-03-31       Impact factor: 6.047

2.  A facile PCR-RFLP method for genotyping of ITPA rs1127354 and rs7270101 polymorphisms.

Authors:  Seyed Ehsan Alavian; Heidar Sharafi; Paniz Shirmast; Seyed Moayed Alavian; Bita Behnava; Mohammad Pouryasin; Maryam Keshvari; Ali Pouryasin
Journal:  J Clin Lab Anal       Date:  2018-04-16       Impact factor: 2.352

Review 3.  Treatment of hepatitis C virus infection for adults and children: Updated Swedish consensus recommendations.

Authors:  Martin Lagging; Rune Wejstål; Gunnar Norkrans; Olle Karlström; Soo Aleman; Ola Weiland; Maria Castedal; Filip Josephson
Journal:  Infect Dis (Lond)       Date:  2015-12-01

4.  Real-world experience with interferon-free, direct acting antiviral therapies in Asian Americans with chronic hepatitis C and advanced liver disease.

Authors:  Christine Y Chang; Pauline Nguyen; An Le; Changqing Zhao; Aijaz Ahmed; Tami Daugherty; Gabriel Garcia; Glen Lutchman; Radhika Kumari; Mindie H Nguyen
Journal:  Medicine (Baltimore)       Date:  2017-02       Impact factor: 1.889

5.  The influence of interleukin 28B polymorphisms on the risk of hepatocellular carcinoma among patients with HBV or HCV infection: An updated meta-analysis.

Authors:  Shaoyou Qin; Jiangbin Wang; Changyu Zhou; Yan Xu; Yonggui Zhang; Xu Wang; Song Wang
Journal:  Medicine (Baltimore)       Date:  2019-09       Impact factor: 1.817

6.  IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections.

Authors:  Belson Rugwizangoga; Maria E Andersson; Jean-Claude Kabayiza; Malin S Nilsson; Brynja Ármannsdóttir; Johan Aurelius; Staffan Nilsson; Kristoffer Hellstrand; Magnus Lindh; Anna Martner
Journal:  Front Cell Infect Microbiol       Date:  2019-10-04       Impact factor: 5.293

7.  Interleukin 28B Polymorphism as a Predictor of Sustained Virological Response to Sofosbuvir-Based Therapy for Hepatitis C Virus Patients.

Authors:  Seham Mahrous Zaki; Hanan Samir Ahmed; Monkez Motieh Yousif; Eman Mohamed Awad
Journal:  Trop Med Infect Dis       Date:  2022-09-05

8.  The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C.

Authors:  Arthur Ivan N Oliveira; Fernanda M Malta; Patricia Momoyo Y Zitelli; Ana Paula M Salles; Michele S Gomes-Gouvea; Ana Catharina S Nastri; Joao Renato R Pinho; Flair J Carrilho; Claudia P Oliveira; Maria Cássia Mendes-Corrêa; Mario G Pessoa; Daniel F Mazo
Journal:  BMC Gastroenterol       Date:  2021-02-23       Impact factor: 3.067

9.  Prevalence of IFNL3 gene polymorphism among blood donors and its relation to genomic profile of ancestry in Brazil.

Authors:  Silvia Renata Cornelio Parolin Rizzo; Diana Gazito; Henrique Pott-Junior; Flavia Roche Moreira Latini; Adauto Castelo
Journal:  Braz J Infect Dis       Date:  2016-10-25       Impact factor: 3.257
  9 in total

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