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Literature DB >> 26250053

Macrophages decide between regeneration and fibrosis in muscle.

Pura Muñoz-Cánoves¹, Antonio L Serrano².

Abstract

Defective muscle regeneration is usually accompanied by excessive matrix accumulation (fibrosis). A recent study reveals how this fibrotic process is prevented to allow successful regeneration, through a timely interplay between macrophages and fibro/adipogenic progenitor cells. This has biomedical relevance for fibrotic muscular dystrophies.

Entities: Disease

Keywords: fibro/adipogenic progenitors; fibrosis; macrophages; nilotinib; regeneration

Mesh：

Year: 2015 PMID： 26250053 DOI： 10.1016/j.tem.2015.07.005

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

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Cited

23 in total

1. Mouse Models of Muscle Fibrosis.

Authors: Antonio L Serrano; Pura Muñoz-Cánoves
Journal: Methods Mol Biol Date: 2021

Review 2. Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Authors: Thomas A Wynn; Kevin M Vannella
Journal: Immunity Date: 2016-03-15 Impact factor: 31.745

3. Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.

Authors: Gregory James; Kathleen A Sluka; Linda Blomster; Leanne Hall; Annina B Schmid; Cindy C Shu; Christopher B Little; James Melrose; Paul W Hodges
Journal: Eur Spine J Date: 2018-06-12 Impact factor: 3.134

4. Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Authors: Gurpreet S Baht; Akshay Bareja; David E Lee; Rajesh R Rao; Rong Huang; Janet L Huebner; David B Bartlett; Corey R Hart; Jason R Gibson; Ian R Lanza; Virginia B Kraus; Simon G Gregory; Bruce M Spiegelman; James P White
Journal: Nat Metab Date: 2020-03-16

Review 5. Changes in Regenerative Capacity through Lifespan.

Authors: Maximina H Yun
Journal: Int J Mol Sci Date: 2015-10-23 Impact factor: 5.923

6. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.

Authors: Ángeles Domínguez-Soto; Alicia Usategui; Mateo de Las Casas-Engel; Miriam Simón-Fuentes; Concha Nieto; Víctor D Cuevas; Miguel A Vega; José Luis Pablos; Ángel L Corbí
Journal: Sci Rep Date: 2017-11-07 Impact factor: 4.379

Macrophages decide between regeneration and fibrosis in muscle.

1. Mouse Models of Muscle Fibrosis.

Review 2. Macrophages in Tissue Repair, Regeneration, and Fibrosis.

3. Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.

4. Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Review 5. Changes in Regenerative Capacity through Lifespan.

6. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.

Review 7. Immunology Guides Skeletal Muscle Regeneration.

Review 8. Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases.

Review 9. Muscle injuries and strategies for improving their repair.

Review 10. PPARβ/δ: Linking Metabolism to Regeneration.