| Literature DB >> 26248738 |
Li Fang Xu1, Xiao Long Zhou1, Qi Wang1, Ji Long Zhou1, Ya Peng Liu1, Qiang Ju1, Hui Wang1, Jin Peng Zhang1, Qing Rong Wu2, Yi Qun Li2, Yu Juan Xia2, Xiu Peng2, Mei Rong Zhang1, Hong Min Yu1, Li Chun Xu1.
Abstract
In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio (OR)=56.74], pesticide exposure (OR=8.90), and indoor decoration pollution (OR=4.32). On the other hand, the factors decreasing the risk of NSCLP were a high education level (OR=0.22) and supplementation of folic acid (OR=0.23) and multivitamins (OR=0.16). Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP.Entities:
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Year: 2015 PMID： 26248738 DOI： 10.3967/bes2015.076
Source DB: PubMed Journal: Biomed Environ Sci ISSN： 0895-3988 Impact factor: 3.118