Carlos H Barrios1, Martin E Blackstein2, Jean-Yves Blay3, Paolo G Casali4, Matias Chacon5, Jin Gu6, Yoon-Koo Kang7, Toshirou Nishida8, Das Purkayastha9, Richard C Woodman10, Peter Reichardt11. 1. PUCRS School of Medicine, Porto Alegre, Brazil. Electronic address: chbe@via-rs.net. 2. Mount Sinai Hospital, Toronto, ON, Canada. Electronic address: martin.blackstein@utoronto.ca. 3. Universite Claude Bernard, Lyon, France. Electronic address: jean-yves.blay@lyon.unicancer.fr. 4. Istituto Nazionale Tumori, Milan, Italy. Electronic address: paolo.casali@istitutotumori.mi.it. 5. Alexander Fleming Institute, Department of Medical Oncology, Buenos Aires, Argentina. Electronic address: matiemi@yahoo.com. 6. Peking University Cancer Hospital, Beijing, China. Electronic address: zlgujin@126.com. 7. University of Ulsan College of Medicine, Seoul, South Korea. Electronic address: ykkang@amc.seoul.kr. 8. National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. Electronic address: tnishida@east.ncc.go.jp. 9. Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. Electronic address: das.purkayastha@novartis.com. 10. Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. Electronic address: richard.woodman@novartis.com. 11. HELIOS Klinikum Berlin-Buch, Berlin, Germany. Electronic address: peter.reichardt@helios-kliniken.de.
Abstract
BACKGROUND: Gastrointestinal stromal tumours (GISTs) are the most common gastrointestinal sarcomas. This global, prospective registry followed patients with advanced or localised GIST (2007-2011). METHODS: Current and evolving diagnostics, treatments and outcome measures in patients with GIST were assessed. Eligible patients were diagnosed with advanced or localised GIST within 15months of registry entry. No treatment plan was prescribed, and no visit schedule was mandated. Treating physicians recorded patient information, including tumour response, diagnostic methods, medications, surgeries performed, mutation status and adverse events leading to dose/medication changes. Survival outcomes were estimated using the Kaplan-Meier method. Other data were analysed using descriptive statistics. RESULTS: The registry included 1663 patients (advanced GIST, n=1095; localised GIST, n=537). Medications (e.g. tyrosine kinase inhibitor use and dosing), disease progression or recurrence and physician assessment of response to treatment in registry patients were consistent with controlled trials and prevailing clinical recommendations. In advanced GIST, estimated 30-month progression-free survival (PFS) (59.8%) and overall survival (OS) (82.7%) were higher than results from previously reported trials (≈40% and ≈70%, respectively). Consistent with treatment guidelines, the most common initial treatments were imatinib for advanced GIST, and complete surgical resection for localised GIST. Computed tomography scans were the most common imaging technique used at diagnosis and follow-up. Mutation analysis was performed at diagnosis in only 15.3% and 14.5% of patients with advanced and localised GIST, respectively. CONCLUSIONS: In this real-world GIST registry, patients with advanced GIST were treated with imatinib and patients with localised GIST received surgical resection, in accordance with prevailing clinical recommendations.
BACKGROUND:Gastrointestinal stromal tumours (GISTs) are the most common gastrointestinal sarcomas. This global, prospective registry followed patients with advanced or localised GIST (2007-2011). METHODS: Current and evolving diagnostics, treatments and outcome measures in patients with GIST were assessed. Eligible patients were diagnosed with advanced or localised GIST within 15months of registry entry. No treatment plan was prescribed, and no visit schedule was mandated. Treating physicians recorded patient information, including tumour response, diagnostic methods, medications, surgeries performed, mutation status and adverse events leading to dose/medication changes. Survival outcomes were estimated using the Kaplan-Meier method. Other data were analysed using descriptive statistics. RESULTS: The registry included 1663 patients (advanced GIST, n=1095; localised GIST, n=537). Medications (e.g. tyrosine kinase inhibitor use and dosing), disease progression or recurrence and physician assessment of response to treatment in registry patients were consistent with controlled trials and prevailing clinical recommendations. In advanced GIST, estimated 30-month progression-free survival (PFS) (59.8%) and overall survival (OS) (82.7%) were higher than results from previously reported trials (≈40% and ≈70%, respectively). Consistent with treatment guidelines, the most common initial treatments were imatinib for advanced GIST, and complete surgical resection for localised GIST. Computed tomography scans were the most common imaging technique used at diagnosis and follow-up. Mutation analysis was performed at diagnosis in only 15.3% and 14.5% of patients with advanced and localised GIST, respectively. CONCLUSIONS: In this real-world GIST registry, patients with advanced GIST were treated with imatinib and patients with localised GIST received surgical resection, in accordance with prevailing clinical recommendations.
Authors: A Deruchie Tan; K Willemsma; A MacNeill; K DeVries; A Srikanthan; C McGahan; T Hamilton; H Li; C D Blanke; C E Simmons Journal: Curr Oncol Date: 2020-06-01 Impact factor: 3.677
Authors: Andre Ignee; Christian Jenssen; Michael Hocke; Yi Dong; Wen-Ping Wang; Xin-Wu Cui; Matthias Woenckhaus; Sevastita Iordache; Adrian Saftoiu; Gudrun Schuessler; Christoph F Dietrich Journal: Endosc Ultrasound Date: 2017 Jan-Feb Impact factor: 5.628