| Literature DB >> 26247899 |
Dimitra Micha1, Dong-Chuan Guo2, Yvonne Hilhorst-Hofstee3, Fop van Kooten4, Dian Atmaja1,5, Eline Overwater1,6, Ferdy K Cayami1,5, Ellen S Regalado2, René van Uffelen7, Hanka Venselaar8, Sultana M H Faradz5, Gerrit Vriend8, Marjan M Weiss1, Erik A Sistermans1, Alessandra Maugeri1, Dianna M Milewicz2, Gerard Pals1, Fleur S van Dijk1.
Abstract
We report three families with arterial aneurysms and dissections in which variants predicted to be pathogenic were identified in SMAD2. Moreover, one variant occurred de novo in a proband with unaffected parents. SMAD2 is a strong candidate gene for arterial aneurysms and dissections given its role in the TGF-β signaling pathway. Furthermore, although SMAD2 and SMAD3 probably have functionally distinct roles in cell signaling, they are structurally very similar. Our findings indicate that SMAD2 mutations are associated with arterial aneurysms and dissections and are in accordance with the observation that patients with pathogenic variants in genes encoding proteins involved in the TGF-β signaling pathway exhibit arterial aneurysms and dissections as key features.Entities:
Keywords: SMAD2; TGF-ß; aneurysm; dissection
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Year: 2015 PMID： 26247899 DOI： 10.1002/humu.22854
Source DB: PubMed Journal: Hum Mutat ISSN： 1059-7794 Impact factor: 4.878