Literature DB >> 26246567

Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity.

Hannah L Turkington1, Mindaugas Juozapaitis2, Philip S Kerry3, Teresa Aydillo4, Juan Ayllon4, Adolfo García-Sastre5, Martin Schwemmle6, Benjamin G Hale7.   

Abstract

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-competent cells but not in cells unable to establish antiviral immunity.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26246567      PMCID： PMC4580192          DOI： 10.1128/JVI.01430-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.

Authors:  Benjamin G Hale; John Steel; Rafael A Medina; Balaji Manicassamy; Jianqiang Ye; Danielle Hickman; Rong Hai; Mirco Schmolke; Anice C Lowen; Daniel R Perez; Adolfo García-Sastre
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

2.  A distinct lineage of influenza A virus from bats.

Authors:  Suxiang Tong; Yan Li; Pierre Rivailler; Christina Conrardy; Danilo A Alvarez Castillo; Li-Mei Chen; Sergio Recuenco; James A Ellison; Charles T Davis; Ian A York; Amy S Turmelle; David Moran; Shannon Rogers; Mang Shi; Ying Tao; Michael R Weil; Kevin Tang; Lori A Rowe; Scott Sammons; Xiyan Xu; Michael Frace; Kim A Lindblade; Nancy J Cox; Larry J Anderson; Charles E Rupprecht; Ruben O Donis
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-27       Impact factor: 11.205

3.  Structural insight into cap-snatching and RNA synthesis by influenza polymerase.

Authors:  Stefan Reich; Delphine Guilligay; Alexander Pflug; Hélène Malet; Imre Berger; Thibaut Crépin; Darren Hart; Thomas Lunardi; Max Nanao; Rob W H Ruigrok; Stephen Cusack
Journal:  Nature       Date:  2014-11-19       Impact factor: 49.962

4.  Structure of influenza A polymerase bound to the viral RNA promoter.

Authors:  Alexander Pflug; Delphine Guilligay; Stefan Reich; Stephen Cusack
Journal:  Nature       Date:  2014-11-19       Impact factor: 49.962

5.  Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions.

Authors:  James M Aramini; Li-Chung Ma; Ligang Zhou; Curtis M Schauder; Keith Hamilton; Brendan R Amer; Timothy R Mack; Hsiau-Wei Lee; Colleen T Ciccosanti; Li Zhao; Rong Xiao; Robert M Krug; Gaetano T Montelione
Journal:  J Biol Chem       Date:  2011-05-26       Impact factor: 5.157

6.  Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation.

Authors:  Denis E Kainov; Konstantin H Müller; Linda L Theisen; Maria Anastasina; Minttu Kaloinen; Claude P Muller
Journal:  J Biol Chem       Date:  2010-12-16       Impact factor: 5.157

7.  Structural basis for dsRNA recognition by NS1 protein of influenza A virus.

Authors:  Ao Cheng; Sek Man Wong; Y Adam Yuan
Journal:  Cell Res       Date:  2009-02       Impact factor: 25.617

8.  A transient homotypic interaction model for the influenza A virus NS1 protein effector domain.

Authors:  Philip S Kerry; Juan Ayllon; Margaret A Taylor; Claudia Hass; Andrew Lewis; Adolfo García-Sastre; Richard E Randall; Benjamin G Hale; Rupert J Russell
Journal:  PLoS One       Date:  2011-03-28       Impact factor: 3.240

Review 9.  Expected and Unexpected Features of the Newly Discovered Bat Influenza A-like Viruses.

Authors:  Wenjun Ma; Adolfo García-Sastre; Martin Schwemmle
Journal:  PLoS Pathog       Date:  2015-06-04       Impact factor: 6.823

10.  Characterization of uncultivable bat influenza virus using a replicative synthetic virus.

Authors:  Bin Zhou; Jingjiao Ma; Qinfang Liu; Bhupinder Bawa; Wei Wang; Reed S Shabman; Michael Duff; Jinhwa Lee; Yuekun Lang; Nan Cao; Abdou Nagy; Xudong Lin; Timothy B Stockwell; Juergen A Richt; David E Wentworth; Wenjun Ma
Journal:  PLoS Pathog       Date:  2014-10-02       Impact factor: 6.823
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  12 in total

1.  Specific Mutations in the PB2 Protein of Influenza A Virus Compensate for the Lack of Efficient Interferon Antagonism of the NS1 Protein of Bat Influenza A-Like Viruses.

Authors:  Teresa Aydillo; Juan Ayllon; Amzie Pavlisin; Carles Martinez-Romero; Shashank Tripathi; Ignacio Mena; Andrés Moreira-Soto; Amanda Vicente-Santos; Eugenia Corrales-Aguilar; Martin Schwemmle; Adolfo García-Sastre
Journal:  J Virol       Date:  2018-03-14       Impact factor: 5.103

2.  Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans.

Authors:  Antonio M Lopes; Patricia Domingues; Roland Zell; Benjamin G Hale
Journal:  J Virol       Date:  2017-10-13       Impact factor: 5.103

3.  Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.

Authors:  Hannah L Turkington; Mindaugas Juozapaitis; Nikos Tsolakos; Eugenia Corrales-Aguilar; Martin Schwemmle; Benjamin G Hale
Journal:  J Virol       Date:  2018-02-12       Impact factor: 5.103

4.  Molecular Dynamics Simulations of Influenza A Virus NS1 Reveal a Remarkably Stable RNA-Binding Domain Harboring Promising Druggable Pockets.

Authors:  Hiba Abi Hussein; Colette Geneix; Camille Cauvin; Daniel Marc; Delphine Flatters; Anne-Claude Camproux
Journal:  Viruses       Date:  2020-05-14       Impact factor: 5.048

5.  Limited adaptation of chimeric H9N2 viruses containing internal genes from bat influenza viruses in chickens.

Authors:  Chaochao Ren; Yinyin Chen; Min Zhang; Ting Zhang; Danqi Bao; Chenyang Lu; Ruixue Xue; Yanjie Zhang; Wenhua Liu; Hongjun Chen; Qiaoyang Teng; Jianmei Yang; Xuesong Li; Zejun Li; Qinfang Liu
Journal:  Vet Microbiol       Date:  2019-04-13       Impact factor: 3.293

6.  Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo.

Authors:  Aitor Nogales; Teresa Aydillo; Gines Ávila-Pérez; Alba Escalera; Kevin Chiem; Richard Cadagan; Marta L DeDiego; Feng Li; Adolfo García-Sastre; Luis Martínez-Sobrido
Journal:  Front Microbiol       Date:  2019-12-17       Impact factor: 5.640

Review 7.  Different but Not Unique: Deciphering the Immunity of the Jamaican Fruit Bat by Studying Its Viriome.

Authors:  Quinnlan David; Tony Schountz; Martin Schwemmle; Kevin Ciminski
Journal:  Viruses       Date:  2022-01-25       Impact factor: 5.048

8.  Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells.

Authors:  Jan Papies; Andrea Sieberg; Daniel Ritz; Daniela Niemeyer; Christian Drosten; Marcel A Müller
Journal:  PLoS One       Date:  2022-03-08       Impact factor: 3.240

9.  The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells.

Authors:  Markus Hoffmann; Nadine Krüger; Pawel Zmora; Florian Wrensch; Georg Herrler; Stefan Pöhlmann
Journal:  PLoS One       Date:  2016-03-30       Impact factor: 3.240

10.  Novel insights into bat influenza A viruses.

Authors:  Kevin Ciminski; Thiprampai Thamamongood; Gert Zimmer; Martin Schwemmle
Journal:  J Gen Virol       Date:  2017-09-14       Impact factor: 3.891
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