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Literature DB >> 26246565

Establishment of a Zebrafish Infection Model for the Study of Wild-Type and Recombinant European Sheatfish Virus.

Verónica Martín¹, Carla Mavian², Alberto López Bueno², Antonio de Molina³, Eduardo Díaz³, Germán Andrés², Antonio Alcami², Alí Alejo⁴.

Abstract

Amphibian-like ranaviruses include pathogens of fish, amphibians, and reptiles that have recently evolved from a fish-infecting ancestor. The molecular determinants of host range and virulence in this group are largely unknown, and currently fish infection models are lacking. We show that European sheatfish virus (ESV) can productively infect zebrafish, causing a lethal pathology, and describe a method for the generation of recombinant ESV, establishing a useful model for the study of fish ranavirus infections.

Entities: Disease Species

Mesh：

Year: 2015 PMID： 26246565 PMCID： PMC4580169 DOI： 10.1128/JVI.01580-15

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. Improved knockout methodology reveals that frog virus 3 mutants lacking either the 18K immediate-early gene or the truncated vIF-2alpha gene are defective for replication and growth in vivo.

Authors: Guangchun Chen; Brian M Ward; Kwang H Yu; V Gregory Chinchar; Jacques Robert
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2. Innate immune evasion mediated by the Ambystoma tigrinum virus eukaryotic translation initiation factor 2alpha homologue.

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3. African swine fever virus multigene family 360 and 530 genes affect host interferon response.

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4. Complete genome sequence of the European sheatfish virus.

Authors: Carla Mavian; Alberto López-Bueno; María Pilar Fernández Somalo; Antonio Alcamí; Alí Alejo
Journal: J Virol Date: 2012-06 Impact factor: 5.103

5. Whole-body analysis of a viral infection: vascular endothelium is a primary target of infectious hematopoietic necrosis virus in zebrafish larvae.

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7. Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses.

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8. Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection.

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9. Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.

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