Airong Shen1, Shengnan Xu2, Yange Ma2, Huanhuan Guo2, Canyu Li2, Chunli Yang2, Shunhong Zou2. 1. Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China shenairzhzh@126.com. 2. Department of Obstetrics and Gynaecology, The Third Affiliated Hospital, Zhengzhou University, Henan, China.
Abstract
AIM: To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis. METHODS: Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed(®) and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV). RESULTS: The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84). CONCLUSIONS: Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.
AIM: To evaluate the diagnostic value of serum cancer antigen (CA)125, CA19-9 and CA15-3 concentrations in endometriosis. METHODS: Case-control studies evaluating CA125, CA19-9 and CA15-3 and endometriosis, published between January 2000 and November 2014 were retrieved from PubMed(®) and Google Scholar. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Subgroup analyses were carried out by ethnicity and disease stage (early, stage I/II; advanced, stage III/IV). RESULTS: The analysis included 12 case-control studies (963 cases, 855 controls). CA125 was associated with endometriosis in the overall population (SMD 0.82, 95% CI 0.72, 0.92), Caucasian subgroup (SMD 1.08, 95% CI 0.96, 1.19), and early (SMD 1.20, 95% CI 0.93, 1.48) or advanced disease (SMD 1.29, 95% CI 1.04, 1.55). CA19-9 was associated with endometriosis in the overall population (SMD 0.48, 95% CI 0.24, 0.72), Caucasian subgroup (SMD 0.31, 95% CI 0.07, 0.55), Asian subgroup (SMD 9.65, 95% CI 7.88, 11.42) and advanced disease (SMD 0.60, 95% CI 0.34, 0.87). CA15-3 was significantly associated with advanced disease (SMD 0.47, 95% CI 0.09, 0.84). CONCLUSIONS: Serum CA125 and CA19-9 may represent useful biomarkers for the noninvasive diagnosis of endometriosis.
Authors: Min-Chul Cho; Jin Hyun Kim; Myeong Hee Jung; In Ae Cho; Hyen Chul Jo; Jeong Kyu Shin; Soon Ae Lee; Won Jun Choi; Jong Hak Lee Journal: Clin Exp Reprod Med Date: 2019-08-13
Authors: Anjali Chandra; A Mi Rho; Kyungah Jeong; Taeri Yu; Ji Hyun Jeon; So Yun Park; Sa Ra Lee; Hye-Sung Moon; Hye Won Chung Journal: Obstet Gynecol Sci Date: 2017-12-18
Authors: Naoko Sasamoto; Mary DePari; Allison F Vitonis; Marc R Laufer; Stacey A Missmer; Amy L Shafrir; Kathryn L Terry Journal: PLoS One Date: 2020-08-24 Impact factor: 3.240