Literature DB >> 26244921

Highly reactive free radicals in electronic cigarette aerosols.

Reema Goel1, Erwann Durand2, Neil Trushin3, Bogdan Prokopczyk3, Jonathan Foulds1, Ryan J Elias2, John P Richie1.   

Abstract

Electronic cigarette (EC) usage has increased exponentially, but limited data are available on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals in EC aerosols by electron paramagnetic resonance spectroscopy (EPR) using the spin-trap phenyl-N-tert-butylnitrone (PBN). Radicals were detected in aerosols from all ECs and eliquids tested (2.5 × 10(13) to 10.3 × 10(13) radicals per puff at 3.3 V) and from eliquid solvents propylene glycol and glycerol and from "dry puffing". These results demonstrate, for the first time, the production of highly oxidizing free radicals from ECs which may present a potential toxicological risk to EC users.

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Year:  2015        PMID： 26244921      PMCID： PMC4961046          DOI： 10.1021/acs.chemrestox.5b00220

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  20 in total

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Authors:  Long-Xi Yu; Boris G Dzikovski; Jack H Freed
Journal:  J Vis Exp       Date:  2012-01-02       Impact factor: 1.355

2.  Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: measurements and model predictions.

Authors:  Soha Talih; Zainab Balhas; Thomas Eissenberg; Rola Salman; Nareg Karaoghlanian; Ahmad El Hellani; Rima Baalbaki; Najat Saliba; Alan Shihadeh
Journal:  Nicotine Tob Res       Date:  2014-09-03       Impact factor: 4.244

3.  Preliminary results of an examination of electronic cigarette user puff topography: the effect of a mouthpiece-based topography measurement device on plasma nicotine and subjective effects.

Authors:  Tory R Spindle; Alison B Breland; Nareg V Karaoghlanian; Alan L Shihadeh; Thomas Eissenberg
Journal:  Nicotine Tob Res       Date:  2014-09-19       Impact factor: 4.244

4.  'Vaping' profiles and preferences: an online survey of electronic cigarette users.

Authors:  Lynne Dawkins; John Turner; Amanda Roberts; Kirstie Soar
Journal:  Addiction       Date:  2013-03-28       Impact factor: 6.526

5.  A new look at radicals in cigarette smoke.

Authors:  Judit Bartalis; W Geoffrey Chan; Jan B Wooten
Journal:  Anal Chem       Date:  2007-05-26       Impact factor: 6.986

Review 6.  Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity.

Authors:  W A Pryor
Journal:  Environ Health Perspect       Date:  1997-06       Impact factor: 9.031

7.  Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.

Authors:  Chad A Lerner; Isaac K Sundar; Hongwei Yao; Janice Gerloff; Deborah J Ossip; Scott McIntosh; Risa Robinson; Irfan Rahman
Journal:  PLoS One       Date:  2015-02-06       Impact factor: 3.240

Review 8.  Oxidative stress and free radicals in COPD--implications and relevance for treatment.

Authors:  Wolfgang Domej; Karl Oettl; Wilfried Renner
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2014-10-17

9.  Comparison of select analytes in exhaled aerosol from e-cigarettes with exhaled smoke from a conventional cigarette and exhaled breaths.

Authors:  Gerald A Long
Journal:  Int J Environ Res Public Health       Date:  2014-10-27       Impact factor: 3.390

Review 10.  Chemical evaluation of electronic cigarettes.

Authors:  Tianrong Cheng
Journal:  Tob Control       Date:  2014-05       Impact factor: 7.552
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  47 in total

1.  Acute Effects of Electronic Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI.

Authors:  Alessandra Caporale; Michael C Langham; Wensheng Guo; Alyssa Johncola; Shampa Chatterjee; Felix W Wehrli
Journal:  Radiology       Date:  2019-08-20       Impact factor: 11.105

Review 2.  The impact of vaping on ocular health: a literature review.

Authors:  Tanisha Martheswaran; Margaret H Shmunes; Yasmyne C Ronquillo; Majid Moshirfar
Journal:  Int Ophthalmol       Date:  2021-04-16       Impact factor: 2.031

3.  The Application of Commercially Available Mobile Cigarette Topography Devices for E-cigarette Vaping Behavior Measurements.

Authors:  Vladimir B Mikheev; Stephanie S Buehler; Marielle C Brinkman; Courtney A Granville; Timothy E Lane; Alexander Ivanov; Kandice M Cross; Pamela I Clark
Journal:  Nicotine Tob Res       Date:  2020-04-21       Impact factor: 4.244

4.  Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns.

Authors:  Yeongkwon Son; Vladimir Mishin; Jeffrey D Laskin; Gediminas Mainelis; Olivia A Wackowski; Cristine Delnevo; Stephan Schwander; Andrey Khlystov; Vera Samburova; Qingyu Meng
Journal:  Chem Res Toxicol       Date:  2019-04-23       Impact factor: 3.739

Review 5.  Mitochondrial toxicity of tobacco smoke and air pollution.

Authors:  Jessica L Fetterman; Melissa J Sammy; Scott W Ballinger
Journal:  Toxicology       Date:  2017-08-22       Impact factor: 4.221

Review 6.  Cardiovascular effects of electronic cigarettes.

Authors:  Neal L Benowitz; Joseph B Fraiman
Journal:  Nat Rev Cardiol       Date:  2017-03-23       Impact factor: 32.419

7.  Characteristics, use patterns and perceptions of electronic cigarette users who were never traditional cigarette smokers.

Authors:  Erin Hammett; Susan Veldheer; Jessica Yingst; Shari Hrabovsky; Jonathan Foulds
Journal:  Addict Behav       Date:  2016-10-22       Impact factor: 3.913

8.  Should electronic cigarette use be covered by clean indoor air laws?

Authors:  Jessica M Yingst; Susan Veldheer; Erin Hammett; Shari Hrabovsky; Jonathan Foulds
Journal:  Tob Control       Date:  2016-09-05       Impact factor: 7.552

9.  Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols.

Authors:  Zachary T Bitzer; Reema Goel; Samantha M Reilly; Ryan J Elias; Alexey Silakov; Jonathan Foulds; Joshua Muscat; John P Richie
Journal:  Free Radic Biol Med       Date:  2018-03-13       Impact factor: 7.376

10.  Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts.

Authors:  Chad A Lerner; Pierrot Rutagarama; Tanveer Ahmad; Isaac K Sundar; Alison Elder; Irfan Rahman
Journal:  Biochem Biophys Res Commun       Date:  2016-06-23       Impact factor: 3.575
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