Literature DB >> 2624469

O dealkylation and aliphatic and aromatic hydroxylation of 3-methoxy-17 beta-estradiol by Aspergillus alliaceus.

J S Williamson1, D E Van Orden, J P Rosazza.   

Abstract

Aspergillus alliaceus UI 315 was examined for its ability to metabolize 3-methoxy-17 beta-estradiol. Preparative-scale incubations with this substrate afforded good yields of 6 beta-hydroxy-17 beta-estradiol, 4-hydroxy-17 beta-estradiol, and 4,6 beta-dihydroxy-17 beta-estradiol, which were identified by high-pressure liquid chromatography, 1H and 13C nuclear magnetic resonance, and high-resolution mass spectrometry.

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Year:  1989        PMID： 2624469      PMCID： PMC203211          DOI： 10.1128/aem.55.11.3029-3031.1989

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  8 in total

1.  Role of 2-hydroxyestrone in estrogen metabolism.

Authors:  J FISHMAN
Journal:  J Clin Endocrinol Metab       Date:  1963-02       Impact factor: 5.958

2.  Direct inhibition of tyrosine hydroxylase activity by catechol estrogens.

Authors:  T Lloyd; J Weisz
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157

3.  A new method for preventing oxidative decomposition of catechol estrogens during chromatography.

Authors:  H P Gelbke; R Knuppen
Journal:  J Chromatogr       Date:  1972-09-20

4.  Microbial transformations of antitumor compounds. 1. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata.

Authors:  R E Betts; D E Walters; J P Rosazza
Journal:  J Med Chem       Date:  1974-06       Impact factor: 7.446

Review 5.  The catechol estrogens.

Authors:  N J MacLusky; F Naftolin; L C Krey; S Franks
Journal:  J Steroid Biochem       Date:  1981-12       Impact factor: 4.292

6.  Steroid structure and function--IX. Molecular conformation of catechol estrogens.

Authors:  W L Duax; J F Griffin; D C Swenson; P D Strong; J Weisz
Journal:  J Steroid Biochem       Date:  1983-03       Impact factor: 4.292

Review 7.  Catecholoestrogens (2-and 4-hydroxyoestrogens): chemistry, biogenesis, metabolism, occurrence and physiological significance.

Authors:  P Ball; R Knuppen
Journal:  Acta Endocrinol Suppl (Copenh)       Date:  1980

8.  Microbiological hydroxylation of estradiol: formation of 2- and 4-hydroxyestradiol by Aspergillus alliaceus.

Authors:  J Williamson; D Van Orden; J P Rosazza
Journal:  Appl Environ Microbiol       Date:  1985-03       Impact factor: 4.792
  8 in total

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