Literature DB >> 26243980

Herb-induced cardiotoxicity from accidental aconitine overdose.

Sujata Sheth1, Elaine Ching Ching Tan1, Hock Heng Tan2, Leslie Tay3.   

Abstract

Patients who overdose on aconite can present with life-threatening ventricular arrhythmia. Aconite must be prepared and used with caution to avoid cardiotoxic effects that can be fatal. We herein describe a case of a patient who had an accidental aconite overdose but survived with no lasting effects. The patient had prepared Chinese herbal medication to treat his pain, which resulted in an accidental overdose of aconite with cardiotoxic and neurotoxic effects. The patient had ventricular tachycardia, bidirectional ventricular tachycardia and ventricular fibrillation. Following treatment with anti-arrhythmic medications, defibrillation and cardiopulmonary resuscitation, he made an uneventful recovery, with no further cardiac arrhythmias reported.

Entities:  

Keywords:  aconite; aconitine herb; bidirectional ventricular tachycardia; cardiotoxic; overdose

Mesh:

Substances:

Year:  2015        PMID: 26243980      PMCID: PMC4520923          DOI: 10.11622/smedj.2015114

Source DB:  PubMed          Journal:  Singapore Med J        ISSN: 0037-5675            Impact factor:   1.858


  9 in total

1.  Aconite poisoning over 5 years: a case series in Hong Kong and lessons towards herbal safety.

Authors:  Sammy Pak Lam Chen; Sau Wah Ng; Wing Tat Poon; Chi Kong Lai; Teresa Man Shan Ngan; Man Li Tse; Thomas Yan Keung Chan; Albert Yan Wo Chan; Tony Wing Lai Mak
Journal:  Drug Saf       Date:  2012-07-01       Impact factor: 5.606

2.  Bidirectional ventricular tachycardia resulting from herbal aconite poisoning.

Authors:  Stephen W Smith; Rajiv R Shah; Jennifer L Hunt; Charles A Herzog
Journal:  Ann Emerg Med       Date:  2005-01       Impact factor: 5.721

3.  Bidirectional ventricular tachycardia.

Authors:  Sergio Richter; Pedro Brugada
Journal:  J Am Coll Cardiol       Date:  2009-09-22       Impact factor: 24.094

4.  Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone.

Authors:  D F Yeih; F T Chiang; S K Huang
Journal:  Heart       Date:  2000-10       Impact factor: 5.994

5.  Severe acute poisoning with homemade Aconitum napellus capsules: toxicokinetic and clinical data.

Authors:  Fabienne Moritz; Patricia Compagnon; Isabelle Guery Kaliszczak; Yann Kaliszczak; Valérie Caliskan; Christophe Girault
Journal:  Clin Toxicol (Phila)       Date:  2005       Impact factor: 4.467

6.  Five cases of aconite poisoning: toxicokinetics of aconitines.

Authors:  Yuji Fujita; Katsutoshi Terui; Megumi Fujita; Atsushi Kakizaki; Norio Sato; Kohei Oikawa; Hidehiko Aoki; Katsuo Takahashi; Shigeatsu Endo
Journal:  J Anal Toxicol       Date:  2007-04       Impact factor: 3.367

Review 7.  Aconite poisoning.

Authors:  Thomas Y K Chan
Journal:  Clin Toxicol (Phila)       Date:  2009-04       Impact factor: 4.467

8.  Clinical features and management of herb-induced aconitine poisoning.

Authors:  Chih-Chuan Lin; Thomas Y K Chan; Jou-Fang Deng
Journal:  Ann Emerg Med       Date:  2004-05       Impact factor: 5.721

9.  A comparative study on the traditional Indian Shodhana and Chinese processing methods for aconite roots by characterization and determination of the major components.

Authors:  Yogini Jaiswal; Zhitao Liang; Peng Yong; Hubiao Chen; Zhongzhen Zhao
Journal:  Chem Cent J       Date:  2013-10-25       Impact factor: 4.215

  9 in total
  5 in total

1.  Adverse drug reactions of Yunnan Baiyao capsule: a multi-center intensive monitoring study in China.

Authors:  Bo Li; Shuo Feng; Zhi-Hong Wu; Joey S W Kwong; Jing Hu; Nan Wu; Gui-Hua Tian; Hong-Cai Shang; Gui-Xing Qiu
Journal:  Ann Transl Med       Date:  2019-03

2.  Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity.

Authors:  Shu Han; Liyuan Bao; Weifei Li; Kaiyang Liu; Ya'nan Tang; Xitao Han; Ziqin Liu; Hongyue Wang; Fengting Zhang; Shuo Mi; Hong Du
Journal:  Evid Based Complement Alternat Med       Date:  2022-04-13       Impact factor: 2.650

3.  REDUCING TOXICITY AND INCREASING EFFICIENCY: ACONITINE WITH LIQUIRITIN AND GLYCYRRHETINIC ACID REGULATE CALCIUM REGULATORY PROTEINS IN RAT MYOCARDIAL CELL.

Authors:  Yuyan Zhang; Li Yu; Weifeng Jin; Hongjing Fan; Min Li; Tianmei Zhou; Haitong Wan; Jiehong Yang
Journal:  Afr J Tradit Complement Altern Med       Date:  2017-06-05

4.  A case report of bidirectional ventricular tachycardia secondary to aconitum toxicity.

Authors:  Germaine Loo; Thon Hon Yong; Colin Yeo
Journal:  J Arrhythm       Date:  2022-03-20

5.  Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms.

Authors:  Xueyan Chen; Huicai Guo; Qing Li; Yu Zhang; Huanlong Liu; Xiaofei Zhang; Kerang Xie; Zhongning Zhu; Qingfeng Miao; Suwen Su
Journal:  Mol Med Rep       Date:  2018-09-12       Impact factor: 2.952

  5 in total

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