| Literature DB >> 26243370 |
Franck Raeppel1, Stéphane L Raeppel2, Eric Therrien1.
Abstract
New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained.Entities:
Keywords: Head group; Molecular docking; Oncology; RON; RON homology model; RTK inhibitors; c-Met
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Year: 2015 PMID： 26243370 DOI： 10.1016/j.bmcl.2015.07.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823