Literature DB >> 26243363

Heavy resistance training is safe and improves bone, function, and stature in postmenopausal women with low to very low bone mass: novel early findings from the LIFTMOR trial.

S L Watson1,2, B K Weeks1,2, L J Weis3, S A Horan1,2, B R Beck4,5,6.   

Abstract

UNLABELLED: The aim of the LIFTMOR (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation) trial is to determine the safety and efficacy of brief, bone-targeted, high-intensity progressive resistance training (HiPRT) with impact loading for postmenopausal women with low bone mass. Preliminary findings indicate the LIFTMOR program is safe and effective.
INTRODUCTION: Despite a lack of notable efficacy, exercise guidelines for osteoporosis typically recommend moderate-intensity exercises, owing to a perceived risk of fracture from high-intensity loading. Indeed, safety concerns alone have prevented the well-recognised preferential response of bone tissue to high-intensity loads from being applied to those who stand to benefit the most. To progress from this therapeutic stalemate, a challenge to conventional wisdom was required. Our goal was to examine the safety and efficacy of HiPRT and impact loading for risk factors of osteoporotic fracture in postmenopausal women with low to very low bone mass.
METHODS: Participants have been randomised to either 8 months of twice-weekly 30-min supervised HiPRT and impact loading or a low-intensity home-based exercise program of the same duration and dose. Testing at baseline and follow-up has included anthropometry; bone, muscle, and fat mass; and functional performance.
RESULTS: Twenty-eight women (66.1 ± 4.8 years, mean lumbar spine T-score -2.15 ± 0.72) have completed the study. HiPRT and impact loading (n = 12) improved height (0.4 ± 0.2 cm vs -0.3 ± 0.1 cm, p = 0.003), femoral neck bone mineral density (0.3 ± 0.5 % vs -2.5 ± 0.8 %, p = 0.016), lumbar spine bone mineral density (1.6 ± 0.9 % vs -1.7 ± 0.6 %, p = 0.005), and functional performance (p < 0.05), compared to controls (n = 16). Compliance has been >87 %. There have been no injuries.
CONCLUSIONS: Brief supervised HiPRT with impact loading is a safe and effective exercise therapy for postmenopausal women with low to very low bone mass.

Entities:  

Keywords:  Back extensor strength; Bone density; Exercise; Kyphosis; Lifting; Osteoporosis

Mesh:

Year:  2015        PMID: 26243363     DOI: 10.1007/s00198-015-3263-2

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  20 in total

1.  Weight lifted in strength training predicts bone change in postmenopausal women.

Authors:  Ellen C Cussler; Timothy G Lohman; Scott B Going; Linda B Houtkooper; Lauve L Metcalfe; Hilary G Flint-Wagner; Robin B Harris; Pedro J Teixeira
Journal:  Med Sci Sports Exerc       Date:  2003-01       Impact factor: 5.411

2.  Strength training preserves the bone mineral density of postmenopausal women without hormone replacement therapy.

Authors:  Danilo Sales Bocalini; Andrey Jorge Serra; Leonardo dos Santos; Neif Murad; Rozeli Ferreira Levy
Journal:  J Aging Health       Date:  2009-02-27

Review 3.  Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations.

Authors:  Catherine Sherrington; Anne Tiedemann; Nicola Fairhall; Jacqueline C T Close; Stephen R Lord
Journal:  N S W Public Health Bull       Date:  2011-06

4.  Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial.

Authors:  M E Nelson; M A Fiatarone; C M Morganti; I Trice; R A Greenberg; W J Evans
Journal:  JAMA       Date:  1994-12-28       Impact factor: 56.272

5.  Regulation of bone formation by applied dynamic loads.

Authors:  C T Rubin; L E Lanyon
Journal:  J Bone Joint Surg Am       Date:  1984-03       Impact factor: 5.284

6.  Effects of walking-only interventions on bone mineral density at various skeletal sites: a meta-analysis.

Authors:  Kerstin M Palombaro
Journal:  J Geriatr Phys Ther       Date:  2005       Impact factor: 3.381

7.  The effects of hormone replacement therapy and resistance training on spine bone mineral density in early postmenopausal women.

Authors:  Gianni F Maddalozzo; Jeffrey J Widrick; Bradley J Cardinal; Kerri M Winters-Stone; Mark A Hoffman; Christine M Snow
Journal:  Bone       Date:  2006-12-29       Impact factor: 4.398

8.  Too Fit To Fracture: exercise recommendations for individuals with osteoporosis or osteoporotic vertebral fracture.

Authors:  L M Giangregorio; A Papaioannou; N J Macintyre; M C Ashe; A Heinonen; K Shipp; J Wark; S McGill; H Keller; R Jain; J Laprade; A M Cheung
Journal:  Osteoporos Int       Date:  2013-11-27       Impact factor: 4.507

9.  Effect of back-strengthening exercise on posture in healthy women 49 to 65 years of age.

Authors:  E Itoi; M Sinaki
Journal:  Mayo Clin Proc       Date:  1994-11       Impact factor: 7.616

10.  Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women.

Authors:  M Sinaki; E Itoi; H W Wahner; P Wollan; R Gelzcer; B P Mullan; D A Collins; S F Hodgson
Journal:  Bone       Date:  2002-06       Impact factor: 4.398

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  24 in total

1.  Intensity is a subjective construct.

Authors:  L M Giangregorio; A Papaioannou; A Heinonen; A M Cheung; J Laprade; M C Ashe; N J MacIntyre; K Shipp; S McGill; J Ravi; H Keller; J D Wark
Journal:  Osteoporos Int       Date:  2016-02-09       Impact factor: 4.507

Review 2.  Exercise, muscle, and the applied load-bone strength balance.

Authors:  L Giangregorio; R El-Kotob
Journal:  Osteoporos Int       Date:  2016-10-13       Impact factor: 4.507

3.  Response to Giangregorio et al.: "Intensity is a subjective construct".

Authors:  B R Beck; S L Watson; L Weis; S A Horan; B K Weeks
Journal:  Osteoporos Int       Date:  2016-03-07       Impact factor: 4.507

Review 4.  Musculoskeletal Health in the Context of Spinal Cord Injury.

Authors:  Jillian M Clark; David M Findlay
Journal:  Curr Osteoporos Rep       Date:  2017-10       Impact factor: 5.096

5.  Chronic joint pain and handgrip strength correlates with osteoporosis in mid-life women: a Singaporean cohort.

Authors:  S Logan; W P P Thu; W K Lay; L Y Wang; J A Cauley; E L Yong
Journal:  Osteoporos Int       Date:  2017-06-24       Impact factor: 4.507

Review 6.  Facilitators and barriers to exercise adherence in patients with osteopenia and osteoporosis: a systematic review.

Authors:  I B Rodrigues; J J Armstrong; J D Adachi; J C MacDermid
Journal:  Osteoporos Int       Date:  2016-10-06       Impact factor: 4.507

7.  Effects of resistance exercise in women with or at risk for breast cancer-related lymphedema.

Authors:  Emily Simonavice; Jeong-Su Kim; Lynn Panton
Journal:  Support Care Cancer       Date:  2016-08-11       Impact factor: 3.603

8.  Postmenopausal Osteoporosis: The Role of Lifestyle in Maintaining Bone Mass and Reducing Fracture Risk.

Authors:  Cynthia Geyer
Journal:  Am J Lifestyle Med       Date:  2016-12-16

Review 9.  Effects of Supervised vs. Unsupervised Training Programs on Balance and Muscle Strength in Older Adults: A Systematic Review and Meta-Analysis.

Authors:  André Lacroix; Tibor Hortobágyi; Rainer Beurskens; Urs Granacher
Journal:  Sports Med       Date:  2017-11       Impact factor: 11.136

10.  Models of care for osteoporosis: A systematic scoping review of efficacy and implementation characteristics.

Authors:  Alicia R Jones; Madhuni Herath; Peter R Ebeling; Helena Teede; Amanda J Vincent
Journal:  EClinicalMedicine       Date:  2021-07-14
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