Literature DB >> 26242928

Making many from few: IL-12p40 as a model for the combinatorial assembly of heterodimeric cytokines.

Kaveh Abdi1, Nevil J Singh2.   

Abstract

How dendritic cells (DCs) gather information from the local milieu at a site of infection or injury and communicate this to influence adaptive immunity is not well understood. We and others have reported that soon after microbial encounter, DCs secrete the p40 subunit of IL-12, by itself, in a monomeric form. Based on recent data that this p40 monomer subsequently associates with p35 released from other cells to generate functional IL-12, we proposed that p40 can function as a DC-derived probe which samples the composition of the local milieu by looking for other binding partners. In this opinion, we discuss how such a sampling function might generate an elaborate combinatorial "code" of heterodimeric cytokines, capable of conveying location-specific information to cells downstream of DC activation, including NK and T cells.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Dendritic cells; Hypothesis; IL-12; Immunological class; Innate activation; T cell differentiation; Tissue immunity

Mesh：

Substances：

Year:  2015        PMID： 26242928      PMCID： PMC4573263          DOI： 10.1016/j.cyto.2015.07.026

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  66 in total

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  10 in total

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