Literature DB >> 26241908

CholesteroNitrones for Stroke.

Maria I Ayuso1, Mourad Chioua2, Emma Martínez-Alonso1, Elena Soriano3, Joan Montaner4, Jaime Masjuán5, Dimitra J Hadjipavlou-Litina6, José Marco-Contelles2, Alberto Alcázar1.   

Abstract

This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26241908     DOI： 10.1021/acs.jmedchem.5b00755

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  9 in total

1.  Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations.

Authors:  Rocío Fernández-Serra; Emma Martínez-Alonso; Alberto Alcázar; Mourad Chioua; José Marco-Contelles; Ricardo Martínez-Murillo; Milagros Ramos; Gustavo V Guinea; Daniel González-Nieto
Journal:  Int J Mol Sci       Date:  2022-07-04       Impact factor: 6.208

2.  Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke.

Authors:  Emma Martínez-Alonso; Alejandro Escobar-Peso; Alicia Aliena-Valero; Germán Torregrosa; Mourad Chioua; Rocío Fernández-Serra; Daniel González-Nieto; Youness Ouahid; Juan B Salom; Jaime Masjuan; José Marco-Contelles; Alberto Alcázar
Journal:  Antioxidants (Basel)       Date:  2022-06-16

3.  Synthesis, Neuroprotection, and Antioxidant Activity of 1,1'-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models.

Authors:  Beatriz Chamorro; David García-Vieira; Daniel Diez-Iriepa; Estíbaliz Garagarza; Mourad Chioua; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Molecules       Date:  2021-02-20       Impact factor: 4.411

4.  Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

Authors:  Alejandro Romero; Eva Ramos; Paloma Patiño; Maria J Oset-Gasque; Francisco López-Muñoz; José Marco-Contelles; María I Ayuso; Alberto Alcázar
Journal:  Front Aging Neurosci       Date:  2016-11-23       Impact factor: 5.750

5.  Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke.

Authors:  Emma Martínez-Alonso; Alejandro Escobar-Peso; Maria I Ayuso; Rafael Gonzalo-Gobernado; Mourad Chioua; Juan J Montoya; Joan Montaner; Israel Fernández; José Marco-Contelles; Alberto Alcázar
Journal:  Antioxidants (Basel)       Date:  2020-03-31

6.  5-Aryl-2-(3,5-dialkyl-4-hydroxyphenyl)-4,4-dimethyl-4H-imidazole 3-Oxides and Their Redox Species: How Antioxidant Activity of 1-Hydroxy-2,5-dihydro-1H-imidazoles Correlates with the Stability of Hybrid Phenoxyl-Nitroxides.

Authors:  Svetlana A Amitina; Elena V Zaytseva; Natalya A Dmitrieva; Alyona V Lomanovich; Natalya V Kandalintseva; Yury A Ten; Ilya A Artamonov; Alexander F Markov; Dmitrii G Mazhukin
Journal:  Molecules       Date:  2020-07-08       Impact factor: 4.411

7.  Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.

Authors:  Daniel Diez-Iriepa; Beatriz Chamorro; Marta Talaván; Mourad Chioua; Isabel Iriepa; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Int J Mol Sci       Date:  2020-10-26       Impact factor: 5.923

8.  Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.

Authors:  Beatriz Chamorro; Daniel Diez-Iriepa; Belén Merás-Sáiz; Mourad Chioua; David García-Vieira; Isabel Iriepa; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; Ricardo Martínez-Murillo; Daniel Gonzàlez-Nieto; Israel Fernández; José Marco-Contelles; María Jesús Oset-Gasque
Journal:  Sci Rep       Date:  2020-08-25       Impact factor: 4.379

9.  Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia-Reperfusion.

Authors:  Beatriz Chamorro; Iwona E Głowacka; Joanna Gotkowska; Rafał Gulej; Dimitra Hadjipavlou-Litina; Francisco López-Muñoz; José Marco-Contelles; Dorota G Piotrowska; María Jesús Oset-Gasque
Journal:  Int J Mol Sci       Date:  2022-03-21       Impact factor: 5.923
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.