Augusto Duarte Faria1, Taiane de Azevedo Cardoso2, Thaise Campos Mondin3, Luciano Dias de Mattos Souza3, Pedro Vieira da Silva Magalhaes4, Cristian Patrick Zeni5, Ricardo Azevedo da Silva3, Flavio Kapczinski6, Karen Jansen7. 1. Universidade Federal do Rio Grande (FURG), Brazil. 2. Universidade Catolica de Pelotas (UCPel), Brazil; University of Texas Health Science Center at Houston (UTHealth), United States. 3. Universidade Catolica de Pelotas (UCPel), Brazil. 4. Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. 5. University of Texas Health Science Center at Houston (UTHealth), United States. 6. Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; University of Texas Health Science Center at Houston (UTHealth), United States. 7. Universidade Catolica de Pelotas (UCPel), Brazil; University of Texas Health Science Center at Houston (UTHealth), United States. Electronic address: Karen.jansen@pq.cnpq.
Abstract
AIM: To assess biological rhythm disruptions among drug-naïve young adults with bipolar disorder (BD), major depressive disorder (MDD), and community controls. METHODS: This was a cross-sectional study nested in a population-based study. BD and MDD were diagnosed using the Structured Clinical Interview for DSM-IV. Biological rhythm disruptions were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). RESULTS: Two hundred seventeen subjects were assessed (49 BD, 74 MDD, and 94 community controls). Biological rhythm disruption was higher in subjects with BD (40.32±9.92; p<0.001) and MDD (36.23±8.71; p<0.001) than community controls (27.67±6.88). Subjects with BD had a higher BRIAN total score (p=0.028) and higher disruption in sleep/social domains (p=0.018) as compared to MDD. In addition, the BRIAN scores were higher in current MDD, euthymic BD, and BD in current episode group, as compared to community controls. LIMITATION: Cross-sectional design. Absence of assessment of biomarkers of biological rhythms. CONCLUSION: Bipolar disorder and major depressive disorder are associated with disruption in biological rhythm. In addition, disruption in sleep/social rhythms is higher in subjects with BD when compared to subjects with MDD. We also verified biological rhythm disruption in subjects with BD during euthymic status, but not in remitted MDD. Regulation of biological rhythm may be a means to identify patients with mood disorders and potentially differentiate MDD from BD.
AIM: To assess biological rhythm disruptions among drug-naïve young adults with bipolar disorder (BD), major depressive disorder (MDD), and community controls. METHODS: This was a cross-sectional study nested in a population-based study. BD and MDD were diagnosed using the Structured Clinical Interview for DSM-IV. Biological rhythm disruptions were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). RESULTS: Two hundred seventeen subjects were assessed (49 BD, 74 MDD, and 94 community controls). Biological rhythm disruption was higher in subjects with BD (40.32±9.92; p<0.001) and MDD (36.23±8.71; p<0.001) than community controls (27.67±6.88). Subjects with BD had a higher BRIAN total score (p=0.028) and higher disruption in sleep/social domains (p=0.018) as compared to MDD. In addition, the BRIAN scores were higher in current MDD, euthymic BD, and BD in current episode group, as compared to community controls. LIMITATION: Cross-sectional design. Absence of assessment of biomarkers of biological rhythms. CONCLUSION:Bipolar disorder and major depressive disorder are associated with disruption in biological rhythm. In addition, disruption in sleep/social rhythms is higher in subjects with BD when compared to subjects with MDD. We also verified biological rhythm disruption in subjects with BD during euthymic status, but not in remitted MDD. Regulation of biological rhythm may be a means to identify patients with mood disorders and potentially differentiate MDD from BD.
Authors: Jan Scott; Bruno Etain; David Miklowitz; Jacob J Crouse; Joanne Carpenter; Steven Marwaha; Daniel Smith; Kathleen Merikangas; Ian Hickie Journal: Neurosci Biobehav Rev Date: 2022-02-17 Impact factor: 8.989
Authors: Ana Paula Francisco; Ana Maria Delgado Cunha; Andre Comiran Tonon; Marina Scop; Salina Mathur; Luisa Caropreso; Benicio Noronha Frey; Maria Paz Hidalgo Journal: Braz J Psychiatry Date: 2022 May-Jun
Authors: Ewa Dopierala; Adrian A Chrobak; Flavio Kapczinski; Michal Michalak; Anna Tereszko; Ewa Ferensztajn-Rochowiak; Dominika Dudek; Daria Dembinska-Krajewska; Marcin Siwek; Jan Jaracz; Janusz K Rybakowski Journal: Braz J Psychiatry Date: 2016-10-20 Impact factor: 2.697