BACKGROUND: The aim of this study was to compare the prosthetic joint infection (PJI) rate after knee revision arthroplasty in two consecutive periods with different antibiotic prophylaxis: short (one day) versus long (five days). METHODS: From January 2007 to September 2010 antibiotic prophylaxis consisted of 800 mg of teicoplanin and 2 g of ceftazidime intravenously and 1 g of ceftazidime two hours after the first dose. From October 2010, it was prolonged post-operatively using vancomycin and ceftazidime intravenously until the fifth day. RESULTS: During the study period, 341 revision surgeries met the inclusion criteria. The PJI rate was lower in the long-prophylaxis group (2.2% versus 6.9%, p=0.049). Prolonged post-operative antibiotic treatment was the only variable associated independently with a lower rate of PJI (odds ratio [OR]: 0.27, 95% confidence interval [CI]: 0.07-0.99).
BACKGROUND: The aim of this study was to compare the prosthetic joint infection (PJI) rate after knee revision arthroplasty in two consecutive periods with different antibiotic prophylaxis: short (one day) versus long (five days). METHODS: From January 2007 to September 2010 antibiotic prophylaxis consisted of 800 mg of teicoplanin and 2 g of ceftazidime intravenously and 1 g of ceftazidime two hours after the first dose. From October 2010, it was prolonged post-operatively using vancomycin and ceftazidime intravenously until the fifth day. RESULTS: During the study period, 341 revision surgeries met the inclusion criteria. The PJI rate was lower in the long-prophylaxis group (2.2% versus 6.9%, p=0.049). Prolonged post-operative antibiotic treatment was the only variable associated independently with a lower rate of PJI (odds ratio [OR]: 0.27, 95% confidence interval [CI]: 0.07-0.99).
Authors: Evelina Tacconelli; Niklas F Müller; Sebastian Lemmen; Nico T Mutters; Stefan Hagel; Elisabeth Meyer Journal: Dtsch Arztebl Int Date: 2016-04-22 Impact factor: 5.594
Authors: Tony S Shen; Alex Gu; Patawut Bovonratwet; Nathaniel T Ondeck; Peter K Sculco; Edwin P Su Journal: Clin Orthop Relat Res Date: 2022-03-01 Impact factor: 4.755
Authors: Ferdinando Iannotti; Paolo Prati; Andrea Fidanza; Raffaele Iorio; Andrea Ferretti; Daniel Pèrez Prieto; Nanne Kort; Bruno Violante; Gennaro Pipino; Alfredo Schiavone Panni; Michael Hirschmann; Marco Mugnaini; Pier Francesco Indelli Journal: Trop Med Infect Dis Date: 2020-12-11