Johannes M S Brath1, Sonja Grill2, Donna P Ankerst2, Ian M Thompson3, Juergen E Gschwend1, Kathleen Herkommer4. 1. Department of Urology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. 2. Departments of Life Sciences and Mathematics, Technische Universitaet Muenchen, Munich, Germany. 3. Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas. 4. Department of Urology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. Electronic address: kathleen.herkommer@tum.de.
Abstract
PURPOSE: Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy. MATERIALS AND METHODS: Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival. RESULTS: Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p <0.001). The 10-year biochemical recurrence-free (62.5%) and prostate cancer specific survival (96.1%) rates did not differ between patients with vs without a family history, nor between the younger vs older patient groups (all p >0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p <0.005) and Gleason score (Gleason 7 vs 6 or less-HR 1.711, 95% CI 1.056-2.774, p = 0.03; Gleason 8 or greater vs 6 or less-HR 4.516, 95% CI 2.776-7.347, p <0.0001) were the only predictors for prostate cancer specific survival. CONCLUSIONS: A family history of prostate cancer has no bearing on long-term outcomes after radical prostatectomy.
PURPOSE: Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy. MATERIALS AND METHODS:Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival. RESULTS: Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p <0.001). The 10-year biochemical recurrence-free (62.5%) and prostate cancer specific survival (96.1%) rates did not differ between patients with vs without a family history, nor between the younger vs older patient groups (all p >0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p <0.005) and Gleason score (Gleason 7 vs 6 or less-HR 1.711, 95% CI 1.056-2.774, p = 0.03; Gleason 8 or greater vs 6 or less-HR 4.516, 95% CI 2.776-7.347, p <0.0001) were the only predictors for prostate cancer specific survival. CONCLUSIONS: A family history of prostate cancer has no bearing on long-term outcomes after radical prostatectomy.
Authors: Mary E Westerman; Boris Gershman; R Jeffrey Karnes; R Houston Thompson; Laureano Rangel; Stephen A Boorjian Journal: World J Urol Date: 2015-12-09 Impact factor: 4.226
Authors: Valentin H Meissner; Jamila G H Strüh; Martina Kron; Lea A Liesenfeld; Stephanie Kranz; Jürgen E Gschwend; Kathleen Herkommer Journal: World J Urol Date: 2020-03-11 Impact factor: 4.226