Chia-Lin Chang1, Douglas J Weber2, Michael C Munin3. 1. Department of Kinesiology, University of San Francisco, San Francisco, CA. Electronic address: changchialin@gmail.com. 2. Defense Advanced Research Projects Agency, Arlington, VA. 3. Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.
Abstract
OBJECTIVE: To investigate the effect of reducing spasticity via onabotulinumtoxin A (Obtx-A) injection on cerebellar activation after chronic stroke during unilateral gripping. DESIGN: Pre-post, case series. SETTING: Outpatient spasticity clinic. PARTICIPANTS: Individuals with chronic spasticity (N=4). INTERVENTIONS: Upper-limb Obtx-A injection. MAIN OUTCOME MEASURES: Functional magnetic resonance imaging (fMRI) was used to measure changes in cerebellar activation before and after upper-limb Obtx-A injection. During fMRI testing, participants performed the same motor task before and after injection, which was 15% and 30% of maximum voluntary isometric gripping measured before Obtx-A injection. RESULTS: After Obtx-A injection, cerebellar activation increased bilaterally during gripping with the paretic hand and during rest. During both pre- and postinjection scans, the paretic hand showed larger cerebellar activation during gripping compared with the nonparetic hand. Cerebellar activation during gripping with the nonparetic hand did not change significantly after Obtx-A injection. CONCLUSIONS: Reducing spasticity via Obtx-A injection may increase cerebellar activation both during gripping tasks with the paretic hand and during rest. To our knowledge, this is the first study that examines changes in cerebellar activation after spasticity treatment with Obtx-A.
OBJECTIVE: To investigate the effect of reducing spasticity via onabotulinumtoxin A (Obtx-A) injection on cerebellar activation after chronic stroke during unilateral gripping. DESIGN: Pre-post, case series. SETTING:Outpatientspasticity clinic. PARTICIPANTS: Individuals with chronic spasticity (N=4). INTERVENTIONS: Upper-limb Obtx-A injection. MAIN OUTCOME MEASURES: Functional magnetic resonance imaging (fMRI) was used to measure changes in cerebellar activation before and after upper-limb Obtx-A injection. During fMRI testing, participants performed the same motor task before and after injection, which was 15% and 30% of maximum voluntary isometric gripping measured before Obtx-A injection. RESULTS: After Obtx-A injection, cerebellar activation increased bilaterally during gripping with the paretic hand and during rest. During both pre- and postinjection scans, the paretic hand showed larger cerebellar activation during gripping compared with the nonparetic hand. Cerebellar activation during gripping with the nonparetic hand did not change significantly after Obtx-A injection. CONCLUSIONS: Reducing spasticity via Obtx-A injection may increase cerebellar activation both during gripping tasks with the paretic hand and during rest. To our knowledge, this is the first study that examines changes in cerebellar activation after spasticity treatment with Obtx-A.
Authors: D M Simpson; D N Alexander; C F O'Brien; M Tagliati; A S Aswad; J M Leon; J Gibson; J M Mordaunt; E P Monaghan Journal: Neurology Date: 1996-05 Impact factor: 9.910
Authors: Marek Harat; Krzysztof Radziszewski; Marcin Rudaś; Małgorzata Okoń; Miroslav Galanda Journal: Neurol Neurochir Pol Date: 2009 Jan-Feb Impact factor: 1.621
Authors: Chia-Lin Chang; Michael C Munin; Elizabeth R Skidmore; Christian Niyonkuru; Lynne M Huber; Douglas J Weber Journal: Arch Phys Med Rehabil Date: 2009-09 Impact factor: 3.966
Authors: Påvel G Lindberg; Johan Gäverth; Anders Fagergren; Peter Fransson; Hans Forssberg; Jörgen Borg Journal: Neurorehabil Neural Repair Date: 2009-05-26 Impact factor: 3.919