Literature DB >> 26239035

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets.

Sylvia T Gunawan1, Kristian Kempe2, Thomas Bonnard3, Jiwei Cui1, Karen Alt3, Lok S Law3, Xiaowei Wang4, Erik Westein4, Georgina K Such5, Karlheinz Peter4, Christoph E Hagemeyer3, Frank Caruso1.   

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antibodies; drug delivery; plasminogen activators; polymer carriers; thrombosis

Mesh：

Substances：

Year:  2015        PMID： 26239035     DOI： 10.1002/adma.201502243

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  14 in total

1.  Platelet microparticle-inspired clot-responsive nanomedicine for targeted fibrinolysis.

Authors:  Christa L Pawlowski; Wei Li; Michael Sun; Kavya Ravichandran; DaShawn Hickman; Clarissa Kos; Gurbani Kaur; Anirban Sen Gupta
Journal:  Biomaterials       Date:  2017-03-14       Impact factor: 12.479

2.  Versatile Polymer Nanocapsules via Redox Competition.

Authors:  Jiajing Zhou; Ming Xu; Zhicheng Jin; Raina M Borum; Nicole Avakyan; Yong Cheng; Wonjun Yim; Tengyu He; Jingcheng Zhou; Zhuohong Wu; Yash Mantri; Jesse V Jokerst
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-05       Impact factor: 15.336

3.  Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa.

Authors:  Thomas Bonnard; Zachary Tennant; Be'Eri Niego; Ruchi Kanojia; Karen Alt; Shweta Jagdale; Lok Soon Law; Sheena Rigby; Robert Lindsay Medcalf; Karlheinz Peter; Christoph Eugen Hagemeyer
Journal:  J Am Heart Assoc       Date:  2017-02-03       Impact factor: 5.501

4.  Development and validation of a high throughput whole blood thrombolysis plate assay.

Authors:  T Bonnard; L S Law; Z Tennant; C E Hagemeyer
Journal:  Sci Rep       Date:  2017-05-24       Impact factor: 4.379

5.  Triggered Release of Loads from Microcapsule-in-Microcapsule Hydrogel Microcarriers: En-Route to an "Artificial Pancreas".

Authors:  Amit Fischer; Sivan Lilienthal; Margarita Vázquez-González; Michael Fadeev; Yang Sung Sohn; Rachel Nechushtai; Itamar Willner
Journal:  J Am Chem Soc       Date:  2020-02-19       Impact factor: 15.419

Review 6.  Smart Nanomaterials for Biomedical Applications-A Review.

Authors:  Magdalena Aflori
Journal:  Nanomaterials (Basel)       Date:  2021-02-04       Impact factor: 5.076

Review 7.  Nanobiotechnology approaches for cardiovascular diseases: site-specific targeting of drugs and nanoparticles for atherothrombosis.

Authors:  Haikun Liu; Geoffrey Pietersz; Karlheinz Peter; Xiaowei Wang
Journal:  J Nanobiotechnology       Date:  2022-02-08       Impact factor: 10.435

Review 8.  New Approaches in Nanomedicine for Ischemic Stroke.

Authors:  Clara Correa-Paz; Andrés da Silva-Candal; Ester Polo; Jérôme Parcq; Denis Vivien; Dusica Maysinger; Beatriz Pelaz; Francisco Campos
Journal:  Pharmaceutics       Date:  2021-05-20       Impact factor: 6.321

Review 9.  Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics.

Authors:  Peng Mi
Journal:  Theranostics       Date:  2020-03-15       Impact factor: 11.556

10.  Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles.

Authors:  Siyu Wang; Xixi Guo; Weijun Xiu; Yang Liu; Lili Ren; Huaxin Xiao; Fang Yang; Yu Gao; Chenjie Xu; Lianhui Wang
Journal:  Sci Adv       Date:  2020-07-29       Impact factor: 14.136
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