Andrea M Abbott1, Lesly A Dossett1, Loretta Loftus1, Weihong Sun1, William Fulp2, Gerald H Sokol3, Christine Laronga4. 1. Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA. 2. Division of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA. 3. Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 4. Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: Christine.largona@moffitt.org.
Abstract
BACKGROUND: Eligibility criteria for intraoperative radiation therapy (IORT) for breast cancer are being established. Impact of age, one criterion, on short-term complications/outcomes was evaluated. METHODS: Institutional Review Board approved retrospective review of early-stage breast cancer patients undergoing breast conserving surgery and IORT from January 2011 to June 2013 were reviewed. Data collected were demographics, comorbidities, histopathology, intraoperative data, adjuvant treatment, and outcomes. Local recurrence (LR), re-excision rates, and complications were evaluated by age group using descriptive statistics. RESULTS: The total number of patients was 100 (43 patients <70, 57 patients ≥70). No significant differences existed between groups in tumor size, operative time, estrogen receptor status, nodal status, tumor grade, or margin excision. Wound infection rates were low for both groups (P = .21). Two LR occurred (both patients ≥70). Median follow-up time was 24 months. CONCLUSION: IORT with its low rate of LR and wound complications may be a reasonable alternative to whole breast irradiation for early-stage breast cancer, regardless of age.
BACKGROUND: Eligibility criteria for intraoperative radiation therapy (IORT) for breast cancer are being established. Impact of age, one criterion, on short-term complications/outcomes was evaluated. METHODS: Institutional Review Board approved retrospective review of early-stage breast cancerpatients undergoing breast conserving surgery and IORT from January 2011 to June 2013 were reviewed. Data collected were demographics, comorbidities, histopathology, intraoperative data, adjuvant treatment, and outcomes. Local recurrence (LR), re-excision rates, and complications were evaluated by age group using descriptive statistics. RESULTS: The total number of patients was 100 (43 patients <70, 57 patients ≥70). No significant differences existed between groups in tumor size, operative time, estrogen receptor status, nodal status, tumor grade, or margin excision. Wound infection rates were low for both groups (P = .21). Two LR occurred (both patients ≥70). Median follow-up time was 24 months. CONCLUSION: IORT with its low rate of LR and wound complications may be a reasonable alternative to whole breast irradiation for early-stage breast cancer, regardless of age.
Authors: Jayant Sharad Vaidya; Uma Jayant Vaidya; Michael Baum; Max Kishor Bulsara; David Joseph; Jeffrey S Tobias Journal: Front Oncol Date: 2022-08-11 Impact factor: 5.738
Authors: Ana Alicia Tejera Hernández; Víctor Manuel Vega Benítez; Juan Carlos Rocca Cardenas; Neith Ortega Pérez; Nieves Rodriguez Ibarria; Juan Carlos Díaz Chico; Juan José García-Granados Alayón; Pedro Pérez Correa; Juan Ramón Hernández Hernández Journal: Ann Surg Treat Res Date: 2020-05-28 Impact factor: 1.766