Literature DB >> 26237446

Tackling Cell Transplantation Anoikis: An Injectable, Shape Memory Cryogel Microcarrier Platform Material for Stem Cell and Neuronal Cell Growth.

Ben Newland1,2, Petra B Welzel1, Heike Newland1, Claudia Renneberg1, Petr Kolar1, Mikhail Tsurkan1, Anne Rosser2, Uwe Freudenberg1, Carsten Werner1.   

Abstract

Highly macroporous semisynthetic cryogel microcarriers can be synthesized for culturing stem cells and neuronal type cells. Growth factors loaded to heparin-containing microcarriers show near zero-order release kinetics and cell-loaded microcarriers can be injected through a fine gauge cannula without negative effect on the cells. These carriers can be applied for cell transplantation applications.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  adherent matrix; biomaterials; cryogels; heparin; microcarriers; neurotrophin; shape memory; star-PEG

Mesh：

Substances：

Year:  2015        PMID： 26237446      PMCID： PMC5656175          DOI： 10.1002/smll.201500898

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  39 in total

1.  Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.

Authors:  Maria Eriksdotter-Jönhagen; Bengt Linderoth; Göran Lind; Layth Aladellie; Ove Almkvist; Niels Andreasen; Kaj Blennow; Nenad Bogdanovic; Vesna Jelic; Ahmadul Kadir; Agneta Nordberg; Erik Sundström; Lars-Olof Wahlund; Anders Wall; Maria Wiberg; Bengt Winblad; Ake Seiger; Per Almqvist; Lars Wahlberg
Journal:  Dement Geriatr Cogn Disord       Date:  2012-02-22       Impact factor: 2.959

Review 2.  Neural transplantation--an experimental tool with clinical possibilities.

Authors:  A Björklund
Journal:  Trends Neurosci       Date:  1991-08       Impact factor: 13.837

3.  Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene.

Authors:  L Yao; W Daly; B Newland; S Yao; W Wang; B K K Chen; N Madigan; A Windebank; A Pandit
Journal:  Gene Ther       Date:  2013-07-25       Impact factor: 5.250

4.  Intrastriatal transplantation of microcarrier-bound human retinal pigment epithelial cells versus sham surgery in patients with advanced Parkinson's disease: a double-blind, randomised, controlled trial.

Authors:  Robert E Gross; Raymond L Watts; Robert A Hauser; Roy Ae Bakay; Heinz Reichmann; Rüdiger von Kummer; William G Ondo; Elke Reissig; Wilhelm Eisner; Heike Steiner-Schulze; Harald Siedentop; Klaus Fichte; Walter Hong; Michael Cornfeldt; Katherine Beebe; Rupert Sandbrink
Journal:  Lancet Neurol       Date:  2011-05-10       Impact factor: 44.182

5.  The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel.

Authors:  Deirdre B Hoban; Ben Newland; Teresa C Moloney; Linda Howard; Abhay Pandit; Eilís Dowd
Journal:  Biomaterials       Date:  2013-09-17       Impact factor: 12.479

6.  Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation.

Authors:  Jianjun Zhang; Talar Tokatlian; Jin Zhong; Quinn K T Ng; Michaela Patterson; William E Lowry; S Thomas Carmichael; Tatiana Segura
Journal:  Adv Mater       Date:  2011-10-14       Impact factor: 30.849

7.  Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms.

Authors:  Marco Timmer; Frauke Müller-Ostermeyer; Verena Kloth; Christian Winkler; Claudia Grothe; Guido Nikkhah
Journal:  Exp Neurol       Date:  2004-05       Impact factor: 5.330

8.  Brain-derived neurotrophic factor suppresses anoikis-induced death of Schwann cells.

Authors:  Masao Koda; Yukio Someya; Yutaka Nishio; Ryo Kadota; Chikato Mannoji; Tomohiro Miyashita; Akihiko Okawa; Atsushi Murata; Masashi Yamazaki
Journal:  Neurosci Lett       Date:  2008-07-24       Impact factor: 3.046

9.  Effective GDNF brain delivery using microspheres--a promising strategy for Parkinson's disease.

Authors:  E Garbayo; C N Montero-Menei; E Ansorena; J L Lanciego; M S Aymerich; M J Blanco-Prieto
Journal:  J Control Release       Date:  2008-12-25       Impact factor: 9.776

10.  Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting.

Authors:  Kristien Reekmans; Nathalie De Vocht; Jelle Praet; Erik Fransen; Debbie Le Blon; Chloé Hoornaert; Jasmijn Daans; Herman Goossens; Annemie Van der Linden; Zwi Berneman; Peter Ponsaerts
Journal:  Stem Cell Res Ther       Date:  2012-12-14       Impact factor: 6.832
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  15 in total

1.  Designing hydrogels for controlled drug delivery.

Authors:  Jianyu Li; David J Mooney
Journal:  Nat Rev Mater       Date:  2016-10-18       Impact factor: 66.308

Review 2.  Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials.

Authors:  Uwe Freudenberg; Yingkai Liang; Kristi L Kiick; Carsten Werner
Journal:  Adv Mater       Date:  2016-07-27       Impact factor: 30.849

3.  Synthesis of ROS scavenging microspheres from a dopamine containing poly(β-amino ester) for applications for neurodegenerative disorders.

Authors:  Ben Newland; Paul Wolff; Dezhong Zhou; Wei Wang; Hong Zhang; Anne Rosser; Wenxin Wang; Carsten Werner
Journal:  Biomater Sci       Date:  2016-03       Impact factor: 6.843

4.  Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy.

Authors:  Roberta Aliperta; Petra B Welzel; Ralf Bergmann; Uwe Freudenberg; Nicole Berndt; Anja Feldmann; Claudia Arndt; Stefanie Koristka; Marcello Stanzione; Marc Cartellieri; Armin Ehninger; Gerhard Ehninger; Carsten Werner; Jens Pietzsch; Jörg Steinbach; Martin Bornhäuser; Michael P Bachmann
Journal:  Sci Rep       Date:  2017-02-16       Impact factor: 4.379

5.  Adipocyte-derived stem cell-based gene therapy upon adipogenic differentiation on microcarriers attenuates type 1 diabetes in mice.

Authors:  Qing Fang; Min Zhai; Shan Wu; Xiaogen Hu; Zhan Hua; Huizhuo Sun; Jing Guo; Wenjian Zhang; Zai Wang
Journal:  Stem Cell Res Ther       Date:  2019-01-22       Impact factor: 6.832

6.  Static and dynamic 3D culture of neural precursor cells on macroporous cryogel microcarriers.

Authors:  Ben Newland; Fanny Ehret; Franziska Hoppe; Dimitri Eigel; Dagmar Pette; Heike Newland; Petra B Welzel; Gerd Kempermann; Carsten Werner
Journal:  MethodsX       Date:  2020-01-23

7.  The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse.

Authors:  David J Harrison; Victoria H Roberton; Ngoc-Nga Vinh; Simon P Brooks; Stephen B Dunnett; Anne E Rosser
Journal:  Cell Transplant       Date:  2018-02       Impact factor: 4.064

8.  Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction.

Authors:  Juan Wang; Hu Yang
Journal:  Sci Rep       Date:  2018-05-08       Impact factor: 4.379

9.  Priming stem cells with protein kinase C activator enhances early stem cell-chondrocyte interaction by increasing adhesion molecules.

Authors:  Dong-Sik Chae; Chang Youn Lee; Jiyun Lee; Hyang-Hee Seo; Chong-Hyuk Choi; Seahyoung Lee; Ki-Chul Hwang
Journal:  Biol Res       Date:  2018-11-01       Impact factor: 5.612

Review 10.  Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment.

Authors:  Arianna Cembran; Kiara F Bruggeman; Richard J Williams; Clare L Parish; David R Nisbet
Journal:  iScience       Date:  2019-12-19
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