Literature DB >> 26236141

Ebola: Working Toward Treatments and Vaccines.

Claire Sykes, Miriam Reisman.   

Abstract

After killing more than 11,000 people in West Africa, the largest known outbreak of the deadly Ebola virus has largely subsided-but development of effective antiviral countermeasures remains a concern. Several experimental products show promise.

Entities:  

Year:  2015        PMID： 26236141      PMCID： PMC4517535     

Source DB:  PubMed          Journal:  P T        ISSN： 1052-1372


  7 in total

1.  Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies.

Authors:  Alison E Heald; Patrick L Iversen; Jay B Saoud; Peter Sazani; Jay S Charleston; Tim Axtelle; Michael Wong; William B Smith; Apinya Vutikullird; Edward Kaye
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

2.  A Recombinant Vesicular Stomatitis Virus Ebola Vaccine.

Authors:  Jason A Regules; John H Beigel; Kristopher M Paolino; Jocelyn Voell; Amy R Castellano; Zonghui Hu; Paula Muñoz; James E Moon; Richard C Ruck; Jason W Bennett; Patrick S Twomey; Ramiro L Gutiérrez; Shon A Remich; Holly R Hack; Meagan L Wisniewski; Matthew D Josleyn; Steven A Kwilas; Nicole Van Deusen; Olivier Tshiani Mbaya; Yan Zhou; Daphne A Stanley; Wang Jing; Kirsten S Smith; Meng Shi; Julie E Ledgerwood; Barney S Graham; Nancy J Sullivan; Linda L Jagodzinski; Sheila A Peel; Judie B Alimonti; Jay W Hooper; Peter M Silvera; Brian K Martin; Thomas P Monath; W Jay Ramsey; Charles J Link; H Clifford Lane; Nelson L Michael; Richard T Davey; Stephen J Thomas
Journal:  N Engl J Med       Date:  2015-04-01       Impact factor: 91.245

3.  Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses.

Authors:  Michelle Meyer; Tania Garron; Ndongala M Lubaki; Chad E Mire; Karla A Fenton; Curtis Klages; Gene G Olinger; Thomas W Geisbert; Peter L Collins; Alexander Bukreyev
Journal:  J Clin Invest       Date:  2015-07-13       Impact factor: 14.808

Review 4.  Favipiravir (T-705), a novel viral RNA polymerase inhibitor.

Authors:  Yousuke Furuta; Brian B Gowen; Kazumi Takahashi; Kimiyasu Shiraki; Donald F Smee; Dale L Barnard
Journal:  Antiviral Res       Date:  2013-09-29       Impact factor: 5.970

5.  A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection.

Authors:  Travis K Warren; Chris A Whitehouse; Jay Wells; Lisa Welch; Alison E Heald; Jay S Charleston; Pete Sazani; St Patrick Reid; Patrick L Iversen; Sina Bavari
Journal:  mBio       Date:  2015-02-10       Impact factor: 7.867

6.  Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections.

Authors:  Patrick L Iversen; Travis K Warren; Jay B Wells; Nicole L Garza; Dan V Mourich; Lisa S Welch; Rekha G Panchal; Sina Bavari
Journal:  Viruses       Date:  2012-11-06       Impact factor: 5.048

7.  Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Authors:  Travis K Warren; Jay Wells; Rekha G Panchal; Kelly S Stuthman; Nicole L Garza; Sean A Van Tongeren; Lian Dong; Cary J Retterer; Brett P Eaton; Gianluca Pegoraro; Shelley Honnold; Shanta Bantia; Pravin Kotian; Xilin Chen; Brian R Taubenheim; Lisa S Welch; Dena M Minning; Yarlagadda S Babu; William P Sheridan; Sina Bavari
Journal:  Nature       Date:  2014-03-02       Impact factor: 49.962
  7 in total
  1 in total

Review 1.  Gene Therapy Leaves a Vicious Cycle.

Authors:  Reena Goswami; Gayatri Subramanian; Liliya Silayeva; Isabelle Newkirk; Deborah Doctor; Karan Chawla; Saurabh Chattopadhyay; Dhyan Chandra; Nageswararao Chilukuri; Venkaiah Betapudi
Journal:  Front Oncol       Date:  2019-04-24       Impact factor: 6.244
  1 in total

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