Literature DB >> 26236052

Development of 6H-Chromeno[3,4-c]pyrido[3',2':4,5]thieno[2,3-e]pyridazin-6-ones as Par-4 Secretagogues.

Mykhaylo S Frasinyuk1, Svitlana P Bondarenko2, Vitaliy M Sviripa3, Ravshan Burikhanov4, Vivek M Rangnekar5, Chunming Liu6, David S Watt7.   

Abstract

Nitrosation and cyclization of 4-(3-aminothieno[2,3-b]pyridine-2-yl)-2H-chromen-2-ones 1 afforded substituted 6H-chromeno[3,4-c]pyrido[3',2':4,5]thieno[2,3-e]pyridazin-6-ones 2 that inhibited the intermediary filament protein, vimentin, at low micromolar concentrations. This inhibition promoted the secretion of Prostate Apoptosis Response-4 protein (Par-4), which selectively triggered apoptosis in prostate cancer cells such as CWR22Rv1, LNCaP-derivative C4-2B, PC-3 and its aggressive analog, PC-3 MM2.

Entities:  

Keywords:  Par-4; Prostate Apoptosis Response-4 protein; coumarin; prostate cancer; pyridazine; vimentin

Year:  2015        PMID： 26236052      PMCID： PMC4518469          DOI： 10.1016/j.tetlet.2015.01.028

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  12 in total

1.  Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients.

Authors:  L Bubendorf; A Schöpfer; U Wagner; G Sauter; H Moch; N Willi; T C Gasser; M J Mihatsch
Journal:  Hum Pathol       Date:  2000-05       Impact factor: 3.466

2.  Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies.

Authors:  Lindsay J Talbot; Syamal D Bhattacharya; Paul C Kuo
Journal:  Int J Biochem Mol Biol       Date:  2012-05-18

3.  Cinnolines; synthesis of 4-hydroxycinnolines.

Authors:  N J LEONARD; S N BOYS
Journal:  J Org Chem       Date:  1946-07       Impact factor: 4.354

4.  The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis.

Authors:  Ravshan Burikhanov; Yanming Zhao; Anindya Goswami; Shirley Qiu; Steven R Schwarze; Vivek M Rangnekar
Journal:  Cell       Date:  2009-07-23       Impact factor: 41.582

Review 5.  Molecular mechanisms of epithelial-mesenchymal transition.

Authors:  Samy Lamouille; Jian Xu; Rik Derynck
Journal:  Nat Rev Mol Cell Biol       Date:  2014-03       Impact factor: 94.444

6.  Synthesis and antiproliferative activity of oxazinocarbazole and N,N-bis(carbazolylmethyl)amine derivatives.

Authors:  Samar Issa; Nadia Walchshofer; Issam Kassab; Hussein Termoss; Soulaima Chamat; Aziz Geahchan; Zouhair Bouaziz
Journal:  Eur J Med Chem       Date:  2010-02-24       Impact factor: 6.514

Review 7.  The basics of epithelial-mesenchymal transition.

Authors:  Raghu Kalluri; Robert A Weinberg
Journal:  J Clin Invest       Date:  2009-06       Impact factor: 14.808

Review 8.  Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches.

Authors:  T Karantanos; P G Corn; T C Thompson
Journal:  Oncogene       Date:  2013-06-10       Impact factor: 9.867

Review 9.  Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic.

Authors:  Angeliki Voulgari; Alexander Pintzas
Journal:  Biochim Biophys Acta       Date:  2009-03-21

10.  Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.

Authors:  Ravshan Burikhanov; Vitaliy M Sviripa; Nikhil Hebbar; Wen Zhang; W John Layton; Adel Hamza; Chang-Guo Zhan; David S Watt; Chunming Liu; Vivek M Rangnekar
Journal:  Nat Chem Biol       Date:  2014-09-14       Impact factor: 15.040
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